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Effects of superimposed tissue weight on regional compliance of injured lungs
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Hedenstierna laboratory. Univ Bari, Dept Emergency & Organ Transplant, Bari, Italy..
Univ Bari, Dept Emergency & Organ Transplant, Bari, Italy..
Univ Bari, Dept Emergency & Organ Transplant, Bari, Italy..
Sahlgrens Univ Hosp, Dept Anaesthesia & Intens Care Med, Gothenburg, Sweden..
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2016 (English)In: Respiratory Physiology & Neurobiology, ISSN 1569-9048, E-ISSN 1878-1519, Vol. 228, 16-24 p.Article in journal (Refereed) PublishedText
Abstract [en]

Computed tomography (CT), together with image analysis technologies, enable the construction of regional volume (V-REG) and local transpulmonary pressure (P-TP,P-REG) maps of the lung. Purpose of this study is to assess the distribution of V-REG vs P-TP,P-REG along the gravitational axis in healthy (HL) and experimental acute lung injury conditions (eALI) at various positive end-expiratory pressures (PEEPS) and inflation volumes. Mechanically ventilated pigs underwent inspiratory hold maneuvers at increasing volumes simultaneously with lung CT scans. eALI was induced via the iv administration of oleic acid. We computed voxel-level V-REG vs P-TP,P-REG curves into eleven isogravitational planes by applying polynomial regressions. Via F-test, we determined that V-REG vs P-TP,P-REG curves derived from different anatomical planes (p-values < 1.4E-3), exposed to different PEEPs (p-values < 1.5E-5) or subtending different lung status (p-values < 3E-3) were statistically different (except for two cases of adjacent planes). Lung parenchyma exhibits different elastic behaviors based on its position and the density of superimposed tissue which can increase during lung injury.

Place, publisher, year, edition, pages
2016. Vol. 228, 16-24 p.
Keyword [en]
Lung compliance, Computed tomography, Acute lung injury, Image registration, Mechanical ventilation, Gravity
National Category
Respiratory Medicine and Allergy
Identifiers
URN: urn:nbn:se:uu:diva-298837DOI: 10.1016/j.resp.2016.03.005ISI: 000376832900003PubMedID: 26976688OAI: oai:DiVA.org:uu-298837DiVA: diva2:948371
Funder
Swedish Heart Lung Foundation
Available from: 2016-07-11 Created: 2016-07-11 Last updated: 2016-07-11Bibliographically approved

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Pellegrini, MariangelaLarsson, AndersHedenstierna, GöranPerchiazzi, Gaetano
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Hedenstierna laboratoryAnaesthesiology and Intensive CareClinical Physiology
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