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Suboptimal Control of Lipid Levels: Results from 29 Countries Participating in the Centralized Pan-Regional Surveys on the Undertreatment of Hypercholesterolaemia (CEPHEUS)
Taipei Vet Gen Hosp, Div Cardiol, Gen Clin Res Ctr, Taipei, Taiwan.;Natl Yang Ming Univ, Taipei 112, Taiwan..
Toulouse Univ Hosp, Dept Cardiol, Toulouse, France..
Natl Heart Hosp, Dept Cardiol, Sofia, Bulgaria..
Johannesburg Hosp, Fac Hlth Sci, Johannesburg, South Africa..
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2016 (English)In: Journal of Atherosclerosis and Thrombosis, ISSN 1880-3873, E-ISSN 1340-3478, Vol. 23, no 5, 567-587 p.Article in journal (Refereed) PublishedText
Abstract [en]

Aim: Five multicentre, cross-sectional Centralized Pan-Regional Surveys on the Undertreatment of Hypercholesterolaemia (CEPHEUS) were conducted in 29 countries across Asia, Western Europe, Eastern Europe, the Middle East, and Africa. The surveys assessed the current use and efficacy of lipid-lowering drugs (LLDs) worldwide and identified possible patient and physician characteristics associated with failure to attain low-density lipoprotein cholesterol (LDL-C) goals. The aim of this analysis was to consolidate the global results from these surveys. Methods: The surveys involved patients aged >= 18 years who had been prescribed LLDs for at least 3 months without dose changes for at least 6 weeks. A single visit was scheduled for data collection, including fasting plasma lipid and glucose levels. Cardiovascular risk profile and LDL-C goal attainment were assessed according to the 2004 updated US National Cholesterol Education Program Adult Treatment Panel III guidelines. Results: In total, 35 121 patients (mean age: 60.4 years) were included, and 90.3% had been prescribed statin monotherapy. Overall, only 49.4% of patients reached their recommended LDL-C level. LDL-C goals were attained in 54.8% (5084/9273) and 22.8% (3287/14 429) of patients were at high and very high cardiovascular risk, respectively. Factors associated with an increased likelihood of LDL-C goal attainment were lower baseline cardiovascular risk; presence of diabetes mellitus, hypertension, or history of cardiovascular disease; and treatment with simvastatin, atorvastatin, or rosuvastatin (vs. all other LLDs). Conclusion: LDL-C goal attainment in patients taking LLDs is suboptimal worldwide, particularly in patients at high and very high cardiovascular risk.

Place, publisher, year, edition, pages
2016. Vol. 23, no 5, 567-587 p.
Keyword [en]
Cardiovascular disease, Hypercholesterolaemia, Lipidlowering drugs, Low-density lipoprotein cholesterol, Undertreatment
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:uu:diva-298929DOI: 10.5551/jat.31179ISI: 000376873100010PubMedID: 26632163OAI: oai:DiVA.org:uu-298929DiVA: diva2:948466
Funder
AstraZeneca
Available from: 2016-07-12 Created: 2016-07-12 Last updated: 2016-07-12Bibliographically approved

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Henriksson, Karin M.
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