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TGF-beta and the TGF-beta Family: Context-Dependent Roles in Cell and Tissue Physiology
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research.
Univ Calif San Francisco, Dept Cell & Tissue Biol, San Francisco, CA 94143 USA..
Univ Tokyo, Grad Sch Med, Dept Mol Pathol, Bunkyo Ku, Tokyo 1130033, Japan..
2016 (English)In: Cold Spring Harbor Perspectives in Biology, ISSN 1943-0264, E-ISSN 1943-0264, Vol. 8, no 5, a021873Article in journal (Refereed) PublishedText
Abstract [en]

The transforming growth factor-beta (TGF-beta) is the prototype of the TGF-beta family of growth and differentiation factors, which is encoded by 33 genes in mammals and comprises homo- and heterodimers. This review introduces the reader to the TGF-beta family with its complexity of names and biological activities. It also introduces TGF-beta as the best-studied factor among the TGF-beta family proteins, with its diversity of roles in the control of cell proliferation and differentiation, wound healing and immune system, and its key roles in pathology, for example, skeletal diseases, fibrosis, and cancer.

Place, publisher, year, edition, pages
2016. Vol. 8, no 5, a021873
National Category
Cell and Molecular Biology
URN: urn:nbn:se:uu:diva-298909DOI: 10.1101/cshperspect.a021873ISI: 000377084600006OAI: oai:DiVA.org:uu-298909DiVA: diva2:948479
Available from: 2016-07-12 Created: 2016-07-12 Last updated: 2016-07-12Bibliographically approved

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Ludwig Institute for Cancer Research
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