Tumor-induced neutrophil extracellular traps-drivers of systemic inflammation and vascular dysfunction
2016 (English)In: Oncoimmunology, ISSN 2162-4011, E-ISSN 2162-402X, Vol. 5, no 3, e1098803Article in journal, Editorial material (Other academic) PublishedText
Neutrophil extracellular traps (NETs) are part of the innate immune defense against microbes, but their contribution to several non-infectious inflammatory conditions has recently been unraveled. We demonstrate that NETs accumulate in the peripheral circulation in tumor-bearing mice, causing systemic inflammation and vascular dysfuntion in organs not affected by tumor cells.
Place, publisher, year, edition, pages
2016. Vol. 5, no 3, e1098803
Cancer, inflammation, NETs, neutrophil extracellular traps, systemic, vascular function
Cancer and Oncology Immunology in the medical area
IdentifiersURN: urn:nbn:se:uu:diva-299093DOI: 10.1080/2162402X.2015.1098803ISI: 000373385700035OAI: oai:DiVA.org:uu-299093DiVA: diva2:948892