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Tumor-induced neutrophil extracellular traps-drivers of systemic inflammation and vascular dysfunction
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Vascular Biology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
2016 (English)In: Oncoimmunology, ISSN 2162-4011, E-ISSN 2162-402X, Vol. 5, no 3, e1098803Article in journal, Editorial material (Other academic) PublishedText
Abstract [en]

Neutrophil extracellular traps (NETs) are part of the innate immune defense against microbes, but their contribution to several non-infectious inflammatory conditions has recently been unraveled. We demonstrate that NETs accumulate in the peripheral circulation in tumor-bearing mice, causing systemic inflammation and vascular dysfuntion in organs not affected by tumor cells.

Place, publisher, year, edition, pages
2016. Vol. 5, no 3, e1098803
Keyword [en]
Cancer, inflammation, NETs, neutrophil extracellular traps, systemic, vascular function
National Category
Cancer and Oncology Immunology in the medical area
Identifiers
URN: urn:nbn:se:uu:diva-299093DOI: 10.1080/2162402X.2015.1098803ISI: 000373385700035OAI: oai:DiVA.org:uu-299093DiVA: diva2:948892
Available from: 2016-07-14 Created: 2016-07-14 Last updated: 2016-07-14Bibliographically approved

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Cedervall, JessicaDimberg, AnnaOlsson, Anna-Karin
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