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Characterization of ESBL disseminating plasmids
Karolinska Univ Hosp, Div Clin Microbiol, Dept Lab Med LABMED, Stockholm, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
2016 (English)In: INFECTIOUS DISEASES, ISSN 2374-4235, Vol. 48, no 1, 18-25 p.Article, review/survey (Refereed) PublishedText
Abstract [en]

Bacteria producing extended-spectrum -lactamases (ESBLs) constitute a globally increasing problem that contributes to treatment complications and elevated death rates. The extremely successful dissemination by ESBL-producing Enterobacteriaceae during the latest decades is a result of the combination of mobilization, evolution and horizontal spread of -lactamase genes on plasmids. In parallel, spread of these plasmids to particularly well-adapted bacterial clones (outbreak clones) has expanded. In this review we describe ESBL-producing bacteria and the genetic mechanisms for dissemination of ESBL resistance. We describe available methodology for studying plasmids and the importance of including plasmids in epidemiological typing as natural parts of the organisms. Plasmids play a fundamental role in how resistance arises and disseminates.

Place, publisher, year, edition, pages
2016. Vol. 48, no 1, 18-25 p.
Keyword [en]
Enterobacteriaceae, resistance, extended-spectrum -lactamase, plasmid typing, epidemiological typing
National Category
Infectious Medicine
URN: urn:nbn:se:uu:diva-299123DOI: 10.3109/23744235.2015.1062536ISI: 000373618300002PubMedID: 26135711OAI: oai:DiVA.org:uu-299123DiVA: diva2:948935
Available from: 2016-07-14 Created: 2016-07-14 Last updated: 2016-07-14Bibliographically approved

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Sandegren, Linus
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