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Fighting an old disease with modern tools: characteristics and molecular detection methods of drug-resistant Mycobacterium tuberculosis
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Res Ctr Borstel, Mol Mycobacteriol, Borstel, Germany..
2016 (English)In: INFECTIOUS DISEASES, ISSN 2374-4235, Vol. 48, no 1, 1-17 p.Article, review/survey (Refereed) Published
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Abstract [en]

Tuberculosis (TB) is an ancient disease, but not a disease of the past. The increasing prevalence of drug-resistant strains of Mycobacterium tuberculosis, the causative agent of TB, demands new measures to combat the situation. Rapid and accurate detection of the pathogen, and its drug susceptibility pattern, is essential for timely initiation of treatment, and ultimately, control of the disease. Molecular-based methods offer a great chance to improve detection of drug-resistant TB; however, their development and usage should be accompanied with a profound understanding of drug resistance mechanisms and circulating M. tuberculosis strains in specific settings, as otherwise, the usefulness of such tests may be limited. This review gives an overview of the history of TB treatment and drug resistance, drug resistance mechanisms for the most commonly used drugs and molecular methods designed to detect drug-resistant strains.

Place, publisher, year, edition, pages
2016. Vol. 48, no 1, 1-17 p.
Keyword [en]
MDR-TB, XDR-TB, drug resistance, next-generation, sequencing, infection control
National Category
Infectious Medicine
Identifiers
URN: urn:nbn:se:uu:diva-299122DOI: 10.3109/23744235.2015.1061205ISI: 000373618300001PubMedID: 26167849OAI: oai:DiVA.org:uu-299122DiVA: diva2:948998
Funder
Swedish Research Council
Available from: 2016-07-15 Created: 2016-07-14 Last updated: 2016-07-15Bibliographically approved

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