The usefulness of Oie-Tozer's model in deriving pharmacokinetic changes in response to changes in the concentration of drug-binding plasma protein
2016 (English)In: Xenobiotica, ISSN 0049-8254, E-ISSN 1366-5928, Vol. 46, no 7, 659-663 p.Article, review/survey (Refereed) PublishedText
1. Oie-Tozer's model can be used to derive changes in the distribution of drugs in relation to changes in the concentration of drug binding plasma proteins.2. Concerns have been raised that the model is invalid for this purpose because it does not account for active drug transport, pH differences between fluids and extracellular tissue binding.3. Here, it is demonstrated that these imperfections do not affect the outcome of the calculation.
Place, publisher, year, edition, pages
2016. Vol. 46, no 7, 659-663 p.
Disposition, distribution, dose fractions, drug concentration, free fraction, model imperfections, pharmacokinetics
Pharmacology and Toxicology
IdentifiersURN: urn:nbn:se:uu:diva-299149DOI: 10.3109/00498254.2015.1104562ISI: 000373943100013OAI: oai:DiVA.org:uu-299149DiVA: diva2:949037