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The usefulness of Oie-Tozer's model in deriving pharmacokinetic changes in response to changes in the concentration of drug-binding plasma protein
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
2016 (English)In: Xenobiotica, ISSN 0049-8254, E-ISSN 1366-5928, Vol. 46, no 7, 659-663 p.Article, review/survey (Refereed) PublishedText
Abstract [en]

1. Oie-Tozer's model can be used to derive changes in the distribution of drugs in relation to changes in the concentration of drug binding plasma proteins.2. Concerns have been raised that the model is invalid for this purpose because it does not account for active drug transport, pH differences between fluids and extracellular tissue binding.3. Here, it is demonstrated that these imperfections do not affect the outcome of the calculation.

Place, publisher, year, edition, pages
2016. Vol. 46, no 7, 659-663 p.
Keyword [en]
Disposition, distribution, dose fractions, drug concentration, free fraction, model imperfections, pharmacokinetics
National Category
Pharmacology and Toxicology
URN: urn:nbn:se:uu:diva-299149DOI: 10.3109/00498254.2015.1104562ISI: 000373943100013OAI: oai:DiVA.org:uu-299149DiVA: diva2:949037
Available from: 2016-07-15 Created: 2016-07-15 Last updated: 2016-07-15Bibliographically approved

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