Protein folding: Vexing debates on a fundamental problem
2016 (English)In: Biophysical Chemistry, ISSN 0301-4622, E-ISSN 1873-4200, Vol. 212, 17-21 p.Article, review/survey (Refereed) PublishedText
The folding of proteins has been at the heart of protein chemistry and biophysics ever since the pioneering experiments by the labs of Fred Richards and Christian Anfinsen. But, despite nearly 60 years of intense research, there are unresolved issues and a lively debate regarding some aspects of this fundamental problem. In this review we give a personal account on some key topics in the field: (i) the nature of the denatured state of a protein, (ii) nucleation sites in the folding reaction, and (iii) the time it takes for individual molecules to traverse the transition state.
Place, publisher, year, edition, pages
2016. Vol. 212, 17-21 p.
Protein folding, Kinetics, Mutagenesis, Denatured state, Transition state, Transition path time
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
IdentifiersURN: urn:nbn:se:uu:diva-299179DOI: 10.1016/j.bpc.2016.03.001ISI: 000374625600003PubMedID: 27018826OAI: oai:DiVA.org:uu-299179DiVA: diva2:949054
FunderSwedish Research Council, 2012- 5096