Performance of plasma calprotectin as a biomarker of early sepsis: a pilot study
2016 (English)In: Biomarkers in Medicine, ISSN 1752-0363, E-ISSN 1752-0371, Vol. 10, no 8, 811-818 p.Article in journal (Refereed) Published
AIM: To determine the performance of plasma calprotectin as a marker of sepsis on intensive care unit (ICU) admission and as a marker of mortality day 30 post-ICU admission.
MATERIALS & METHODS: Consecutive ICU patients were allocated to: sepsis (n = 15), postoperative inflammation (n = 23) and intoxication without inflammation (n = 7) groups.
RESULTS: Calprotectin was 4.3 (2.6-8.2; mg/l; median [interquartile range]) in the sepsis, 2.8 (1.6-4.4) in the postoperative and 0.7 (0.4-1.6) in the intoxication groups. Area under the receiver operating characteristic curve for sepsis versus intoxication group was: 0.95, for sepsis versus postoperative groups: 0.65 and for survivors versus nonsurvivors: 0.70.
CONCLUSION: Calprotectin was a sensitive marker of systemic inflammation, is a potential sepsis marker and performed well as mortality predictor in this pilot study.
Place, publisher, year, edition, pages
2016. Vol. 10, no 8, 811-818 p.
Anesthesiology and Intensive Care
IdentifiersURN: urn:nbn:se:uu:diva-299540DOI: 10.2217/bmm-2016-0032PubMedID: 27414210OAI: oai:DiVA.org:uu-299540DiVA: diva2:949708