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Performance of plasma calprotectin as a biomarker of early sepsis: a pilot study
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
Department of Anaesthesia, Intensive Care & Surgical Services, Karolinska University Hospital, Huddinge, Stockholm, Sweden..
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2016 (English)In: Biomarkers in Medicine, ISSN 1752-0363, E-ISSN 1752-0371, Vol. 10, no 8, 811-818 p.Article in journal (Refereed) Published
Abstract [en]

AIM: To determine the performance of plasma calprotectin as a marker of sepsis on intensive care unit (ICU) admission and as a marker of mortality day 30 post-ICU admission.

MATERIALS & METHODS: Consecutive ICU patients were allocated to: sepsis (n = 15), postoperative inflammation (n = 23) and intoxication without inflammation (n = 7) groups.

RESULTS: Calprotectin was 4.3 (2.6-8.2; mg/l; median [interquartile range]) in the sepsis, 2.8 (1.6-4.4) in the postoperative and 0.7 (0.4-1.6) in the intoxication groups. Area under the receiver operating characteristic curve for sepsis versus intoxication group was: 0.95, for sepsis versus postoperative groups: 0.65 and for survivors versus nonsurvivors: 0.70.

CONCLUSION: Calprotectin was a sensitive marker of systemic inflammation, is a potential sepsis marker and performed well as mortality predictor in this pilot study.

Place, publisher, year, edition, pages
2016. Vol. 10, no 8, 811-818 p.
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Anesthesiology and Intensive Care
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URN: urn:nbn:se:uu:diva-299540DOI: 10.2217/bmm-2016-0032PubMedID: 27414210OAI: oai:DiVA.org:uu-299540DiVA: diva2:949708
Available from: 2016-07-22 Created: 2016-07-22 Last updated: 2016-09-24Bibliographically approved
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Söderberg, EwaLarsson, AndersNilsen, TomEriksson, MatsLipcsey, Miklós
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Anaesthesiology and Intensive CareBiochemial structure and functionHedenstierna laboratory
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