Branched-chain amino acids are associated with cardiometabolic risk profiles found already in lean, overweight and obese young
2016 (English)In: Journal of Nutritional Biochemistry, ISSN 0955-2863, E-ISSN 1873-4847, Vol. 32, 123-127 p.Article in journal (Refereed) PublishedText
Cardiovascular risk is increased in obese subjects. Nevertheless, some overweight and obese remain cardiometabolically healthy (CMH), and normal-weight persons develop cardiovascular disease (CVD). Herein, we investigate the potential of branched-chain amino acids (BCAAs) to identify an increased CVD risk in a cross-sectional study of 666 adults and juveniles (age 25.3 +/- 12.8 years), classified as lean, overweight or obese. Cardiometabolic groups were defined by cutoffs of systolic blood pressure <130 mmHg, diastolic blood pressure<85 mmHg, glucose <125 mg/dl, triglycerides <150 mg/dl, HDL-cholesterol>40 mg/dl (males), HDL-cholesterol>50 mg/dl (females) and HOMA-IR<5. CMH had <= 1 cutoff, and cardiometabolically abnormal (CMA) had >= 2 cutoffs. Amino acids were measured by high-pressure lipid chromatography after precipitation of serum with perchloric acid and derivatization with o-phthalaldehyde. Valine correlated with 5, leucine correlated with 3 and isoleucine correlated with 5 of the cardiac risk classification factors. Valine and leucine were significantly higher in the obese (P<.001, P=.015, respectively), overweight (P<.001, P=.015, respectively) and lean (P=.024, P=.012, respectively) CMA compared to CMH subjects. Isoleucine showed except of the lean group the same results. Taken together, BCAAs, especially valine and leucine, are proposed as a cardiometabolic risk marker independent of body mass index (BMI) category.
Place, publisher, year, edition, pages
2016. Vol. 32, 123-127 p.
Branched-chain amino acids, Cardiometabolic risk, Body mass index
Nutrition and Dietetics Cell and Molecular Biology
IdentifiersURN: urn:nbn:se:uu:diva-299588DOI: 10.1016/j.jnutbio.2016.02.007ISI: 000377634300014PubMedID: 27142745OAI: oai:DiVA.org:uu-299588DiVA: diva2:949711