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Collagen epitope expression on B cells is sufficient to confer tolerance to collagen-induced arthritis
Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Rheumatol & Inflammat Res, Box 480, SE-40530 Gothenburg, Sweden..
Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Rheumatol & Inflammat Res, Box 480, SE-40530 Gothenburg, Sweden.;Sahlgrens Univ Hosp, Gothenburg, Sweden..
Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Rheumatol & Inflammat Res, Box 480, SE-40530 Gothenburg, Sweden.;Sahlgrens Univ Hosp, Gothenburg, Sweden..
Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Rheumatol & Inflammat Res, Box 480, SE-40530 Gothenburg, Sweden..
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2016 (English)In: Arthritis Research & Therapy, ISSN 1478-6354, E-ISSN 1478-6362, Vol. 18, 140Article in journal (Refereed) Published
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Abstract [en]

Background: The mechanisms underlying tolerance induction and maintenance in autoimmune arthritis remain elusive. In a mouse model of rheumatoid arthritis, collagen type II (CII)-induced arthritis, we explore the contribution of B cells to antigen-specific tolerance. Methods: To generate expression of the CII-peptide specifically on B-cell major histocompatibility complex type II, lentiviral-based gene therapy including a B-cell-specific Igk promoter was used. Results: Presentation of the CII-peptide on B cells significantly reduced the frequency and severity of arthritis as well as the serum levels of CII -specific IgG antibodies. Further, both frequency and suppressive function of regulatory T cells were increased in tolerized mice. Adoptive transfer of regulatory T cells from tolerized mice to naive mice ameliorated the development of CII-induced arthritis. Conclusion: Our data suggest that endogenous presentation of the CII-peptide on B cells is one of the key contributors to arthritis tolerance induction and maintenance.

Place, publisher, year, edition, pages
2016. Vol. 18, 140
Keyword [en]
Tolerance, B cells, B lymphocytes, Arthritis, Collagen, Collagen type II, Gene therapy, Antigen presentation
National Category
Rheumatology and Autoimmunity
Identifiers
URN: urn:nbn:se:uu:diva-299569DOI: 10.1186/s13075-016-1037-7ISI: 000377977600002PubMedID: 27301320OAI: oai:DiVA.org:uu-299569DiVA: diva2:949740
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Swedish Research Council
Available from: 2016-07-22 Created: 2016-07-22 Last updated: 2017-11-28Bibliographically approved

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Kihlberg, Jan

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