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Catheter closure of atrial septal defect in the elderly (>= 65 years): A worthwhile procedure
Halmstad Cty Hosp, Dept Med, Halmstad, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Coagulation and inflammation science. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
Sahlgrens Univ Hosp, Dept Med, Ostra, Sweden.;Gothenburg Univ, Sahlgrenska Acad, Inst Med, S-41124 Gothenburg, Sweden..
Karolinska Univ Hosp, Dept Cardiol, Stockholm, Sweden..
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2016 (English)In: International Journal of Cardiology, ISSN 0167-5273, E-ISSN 1874-1754, Vol. 218, 25-30 p.Article in journal (Refereed) PublishedText
Abstract [en]

Background: Secundum atrial septal defect (ASD2) is one of the most common cardiac malformations diagnosed in adult life. Catheter closure has made treatment possible even in patients of high age. However, published outcome data for elderly patients is limited. The aim of this study was to report, on a national basis, the long-term outcome of ASD2 catheter closure in the elderly. Material and results: We report the clinical and echocardiographic outcome of catheter closure of ASD2 in 148 patients aged 65-87 years. Data was obtained from a national registry, medical records and a questionnaire. The proportion of patients in NYHAI increased from 34% to 61% (p < 0.001) one year after closure and remained stable at the latest follow-up 4,4 (SD 2,6) years post-closure. The proportion of patients with moderate/severe enlargement of the right ventricle and atrium fell from 77% and 76% to 25% and 40%, respectively, (p < 0.001) and right ventricular systolic pressure dropped significantly. Improvement of NYHA class was associated with reduced right ventricular systolic pressure but not with remodelling of the right heart. NYHA deteriorated in 9 patients, despite reduced right ventricular size. Overall, the prevalence of atrial fibrillation was unchanged after closure. Major complication rate was 2% and there was no procedure-or device-related mortality. Conclusion: Catheter closure of ASD2 in the elderly is a worthwhile procedure since it improves symptoms and has a low complication rate. However, a subset of patients do not improve, in which we suggest that concealed left ventricular dysfunction may play a causative role.

Place, publisher, year, edition, pages
2016. Vol. 218, 25-30 p.
Keyword [en]
Atrial septal defect, Elderly, Catheter closure, Adult congenital heart disease, SWEDCON
National Category
Cardiac and Cardiovascular Systems
URN: urn:nbn:se:uu:diva-299541DOI: 10.1016/j.ijcard.2016.05.024ISI: 000377856300004PubMedID: 27232907OAI: oai:DiVA.org:uu-299541DiVA: diva2:949819
Available from: 2016-07-25 Created: 2016-07-22 Last updated: 2016-07-25Bibliographically approved

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Christersson, Christina
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