Pancreatic islet blood flow and its measurement
2016 (English)In: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 121, no 2, 81-95 p.Article, review/survey (Refereed) PublishedText
Pancreatic islets are richly vascularized, and islet blood vessels are uniquely adapted to maintain and support the internal milieu of the islets favoring normal endocrine function. Islet blood flow is normally very high compared with that to the exocrine pancreas and is autonomously regulated through complex interactions between the nervous system, metabolites from insulin secreting beta-cells, endothelium derived mediators, and hormones. The islet blood flow is normally coupled to the needs for insulin release and is usually disturbed during glucose intolerance and overt diabetes. The present review provides a brief background on islet vascular function and especially focuses on available techniques to measure islet blood perfusion. The gold standard for islet blood flow measurements in experimental animals is the microsphere technique, and its advantages and disadvantages will be discussed. In humans there are still no methods to measure islet blood flow selectively, but new developments in radiological techniques hold great hopes for the future.
Place, publisher, year, edition, pages
2016. Vol. 121, no 2, 81-95 p.
Blood flow measurements, islet blood flow, microspheres, pancreatic islets
IdentifiersURN: urn:nbn:se:uu:diva-299775DOI: 10.3109/03009734.2016.1164769ISI: 000376695600004PubMedID: 27124642OAI: oai:DiVA.org:uu-299775DiVA: diva2:950126
FunderSwedish Research CouncilSwedish Diabetes AssociationSwedish Childhood Cancer FoundationNovo Nordisk