BDNF DNA methylation changes as a biomarker of psychiatric disorders: literature review and open access database analysis
2016 (English)In: Behavioral and Brain Functions, ISSN 1744-9081, E-ISSN 1744-9081, Vol. 12, 17Article, review/survey (Refereed) PublishedText
Brain-derived neurotrophic factor (BDNF) plays an important role in nervous system development and function and it is well established that BDNF is involved in the pathogenesis of a wide range of psychiatric disorders. Recently, numerous studies have associated the DNA methylation level of BDNF promoters with certain psychiatric phenotypes. In this review, we summarize data from current literature as well as from our own analysis with respect to the correlation of BDNF methylation changes with psychiatric disorders and address questions about whether DNA methylation related to the BDNF can be useful as biomarker for specific neuropsychiatric disorders.
Place, publisher, year, edition, pages
2016. Vol. 12, 17
BDNF, DNA methylation, Biomarkers, Psychiatric disorders
IdentifiersURN: urn:nbn:se:uu:diva-299766DOI: 10.1186/s12993-016-0101-4ISI: 000377061100001PubMedID: 27267954OAI: oai:DiVA.org:uu-299766DiVA: diva2:950135
FunderSwedish Research CouncilThe Swedish Brain Foundation