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BDNF DNA methylation changes as a biomarker of psychiatric disorders: literature review and open access database analysis
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology. Karolinska Inst, Karolinska Univ Hosp, Dept Clin Neurosci, CMM L8-04, S-17176 Stockholm, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.
2016 (English)In: Behavioral and Brain Functions, ISSN 1744-9081, E-ISSN 1744-9081, Vol. 12, 17Article, review/survey (Refereed) Published
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Abstract [en]

Brain-derived neurotrophic factor (BDNF) plays an important role in nervous system development and function and it is well established that BDNF is involved in the pathogenesis of a wide range of psychiatric disorders. Recently, numerous studies have associated the DNA methylation level of BDNF promoters with certain psychiatric phenotypes. In this review, we summarize data from current literature as well as from our own analysis with respect to the correlation of BDNF methylation changes with psychiatric disorders and address questions about whether DNA methylation related to the BDNF can be useful as biomarker for specific neuropsychiatric disorders.

Place, publisher, year, edition, pages
2016. Vol. 12, 17
Keyword [en]
BDNF, DNA methylation, Biomarkers, Psychiatric disorders
National Category
Neurology
Identifiers
URN: urn:nbn:se:uu:diva-299766DOI: 10.1186/s12993-016-0101-4ISI: 000377061100001PubMedID: 27267954OAI: oai:DiVA.org:uu-299766DiVA: diva2:950135
Funder
Swedish Research CouncilThe Swedish Brain Foundation
Available from: 2016-07-27 Created: 2016-07-27 Last updated: 2017-11-28Bibliographically approved

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Zheleznyakova, Galina Y.Schiöth, Helgi B.

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