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The impact of the concentration of drug binding plasma proteins on drug distribution according to Øie-Tozer's model
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
2016 (English)In: Xenobiotica, ISSN 0049-8254, E-ISSN 1366-5928, Vol. 46, no 4, 307-314 p.Article in journal (Refereed) PublishedText
Abstract [en]

New equations have been developed from an updated version of Oie-Tozer's model expressing how the free concentration and volume of distribution change in relation to changes in the concentration of drug binding plasma proteins. This updated model accommodates more than one drug binding plasma protein to contribute to the plasma protein binding. Demonstrations of the model show that variability in the concentration of one plasma protein has considerably less impact on the free drug concentration and volume of distribution if other plasma proteins contribute to binding, than if they don't.

Place, publisher, year, edition, pages
2016. Vol. 46, no 4, 307-314 p.
Keyword [en]
Disposition, dose fraction, free fraction, orosomucoid, serum albumin
National Category
Pharmacology and Toxicology
Identifiers
URN: urn:nbn:se:uu:diva-299808DOI: 10.3109/00498254.2015.1074764ISI: 000378173700003PubMedID: 26259025OAI: oai:DiVA.org:uu-299808DiVA: diva2:950139
Available from: 2016-07-27 Created: 2016-07-27 Last updated: 2016-07-27Bibliographically approved

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