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Associations between the FKBP5 haplotype, exposure to violence and anxiety in females
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Child and Adolescent Psychiatry. Karolinska Inst, Ctr Neurodev Disorders, Karolinska Inst KIND, Dept Womens & Childrens Hlth,Pediat Neuropsychiat, S-17177 Stockholm, Sweden.ORCID iD: 0000-0003-1033-2618
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neuro-psycho-pharmacology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Clinical Research, County of Västmanland.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Clinical Research, County of Västmanland.
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2016 (English)In: Psychoneuroendocrinology, ISSN 0306-4530, E-ISSN 1873-3360, Vol. 72, 196-204 p.Article in journal (Refereed) Published
Abstract [en]

The gene that encodes the FK506-binding protein 5 (FKBP5) is regarded as a candidate for investigating how negative life events interact with a genetic predisposition to stress-related disorders, such as depression and anxiety. Given the role of FKBP5 as an important regulator of stress responses, we aimed to investigate if single-nucleotide polymorphisms (SNPs) in FKBP5-in the presence/absence of exposure to violence-are associated with symptoms of depression and anxiety. Data from two community-based samples of adolescents (n=1705) and young adults (n=1800) regarding ratings on depression, anxiety, exposure to violence and FKBP5 genotype were collected. A risk haplogenotype including the minor alleles of seven common SNPs in the FKBP5 (rs3800373, rs9296158, rs7748266, rs1360780, rs9394309, rs9470080 and rs4713916) conferred higher ratings on anxiety among females, but not males, in the presence of violence. Exposure to violence and female sex were associated with higher ratings on both depression and anxiety, with the exception of ratings on depression among young adults, on which sex had no effect. Ratings on depression were not associated with the haplogenotype. These findings may correspond to differences in the regulation of the HPA axis and with the higher vulnerability to anxiety in females.

Place, publisher, year, edition, pages
2016. Vol. 72, 196-204 p.
Keyword [en]
FKBP5; Anxiety; Depression; Exposure to violence; Sex differences
National Category
Psychiatry
Identifiers
URN: urn:nbn:se:uu:diva-299873DOI: 10.1016/j.psyneuen.2016.07.206ISI: 000382594600026PubMedID: 27448712OAI: oai:DiVA.org:uu-299873DiVA: diva2:950244
Funder
The Swedish Brain FoundationÅke Wiberg FoundationForte, Swedish Research Council for Health, Working Life and WelfarePublic Health Agency of Sweden , 2011-0627 2015-00897
Available from: 2016-07-28 Created: 2016-07-28 Last updated: 2016-10-05Bibliographically approved

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Isaksson, JohanComasco, ErikaÅslund, CeciliaRehn, MattiasNilsson, Kent W.
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Child and Adolescent PsychiatryNeuro-psycho-pharmacologyCentre for Clinical Research, County of Västmanland
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