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CKD Prevalence Varies across the European General Population
Amsterdam Med Ctr, European Renal Assoc European Dialysis & Transpla, Dept Med Informat, Meibergdreef 9, NL-1100 DD Amsterdam, Netherlands..
Amsterdam Med Ctr, European Renal Assoc European Dialysis & Transpla, Dept Med Informat, Meibergdreef 9, NL-1100 DD Amsterdam, Netherlands..
Univ Cattolica Sacro Cuore, Columbus Gemelli Univ Hosp, Div Nephrol & Dialysis, I-00168 Rome, Italy..
Norwegian Univ Sci & Technol, Fac Med, St Olavs Hosp, Dept Nephrol, N-7034 Trondheim, Norway..
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2016 (English)In: Journal of the American Society of Nephrology, ISSN 1046-6673, E-ISSN 1533-3450, Vol. 27, no 7, 2135-2147 p.Article in journal (Refereed) PublishedText
Abstract [en]

CKD prevalence estimation is central to CKD management and prevention planning at the population level. This study estimated CKD prevalence in the European adult general population and investigated international variation in CKD prevalence by age, sex, and presence of diabetes, hypertension, and obesity. We collected data from 19 general-population studies from 13 European countries. CKD stages 1-5 was defined as eGFR <60 ml/min per 1.73 m(2), as calculated by the CKD-Epidemiology Collaboration equation, or albuminuria >30 mg/g, and CKD stages 3-5 was defined as eGFR<60 ml/min per 1.73 m(2). CKD prevalence was age- and sex-standardized to the population of the 27 Member States of the European Union (EU27). We found considerable differences in both CKD stages 1-5 and CKD stages 3-5 prevalence across European study populations. The adjusted CKD stages 1-5 prevalence varied between 3.31% (95% confidence interval [95% CI], 3.30% to 3.33%) in Norway and 17.3% (95% Cl, 16.5% to 18.1%) in northeast Germany. The adjusted CKD stages 3-5 prevalence varied between 1.0% (95% CI, 0.7% to 1.3%) in central Italy and 5.9% (95% CI, 5.2% to 6.6%) in northeast Germany. The variation in CKD prevalence stratified by diabetes, hypertension, and obesity status followed the same pattern as the overall prevalence. In conclusion, this large-scale attempt to carefully characterize CKD prevalence in Europe identified substantial variation in CKD prevalence that appears to be due to factors other than the prevalence of diabetes, hypertension, and obesity.

Place, publisher, year, edition, pages
2016. Vol. 27, no 7, 2135-2147 p.
National Category
Urology and Nephrology
Identifiers
URN: urn:nbn:se:uu:diva-299850DOI: 10.1681/ASN.2015050542ISI: 000378824800027PubMedID: 26701975OAI: oai:DiVA.org:uu-299850DiVA: diva2:950273
Funder
EU, European Research Council, HEALTH-F2-2009-241544
Available from: 2016-07-29 Created: 2016-07-28 Last updated: 2016-07-29Bibliographically approved

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Ärnlöv, Johan
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