uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Comparison of Early-Phase C-11-Deuterium-L-Deprenyl and C-11-Pittsburgh Compound B PET for Assessing Brain Perfusion in Alzheimer Disease
Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Translat Alzheimer Neurobiol, Ctr Alzheimer Res, SE-14157 Stockholm, Sweden..
Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Translat Alzheimer Neurobiol, Ctr Alzheimer Res, SE-14157 Stockholm, Sweden.;Univ Manchester, Inst Brain Behav & Mental Hlth, Wolfson Mol Imaging Ctr, Manchester, Lancs, England..
Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Translat Alzheimer Neurobiol, Ctr Alzheimer Res, SE-14157 Stockholm, Sweden..
Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Translat Alzheimer Neurobiol, Ctr Alzheimer Res, SE-14157 Stockholm, Sweden..
Show others and affiliations
2016 (English)In: Journal of Nuclear Medicine, ISSN 0161-5505, E-ISSN 1535-5667, Vol. 57, no 7, 1071-1077 p.Article in journal (Refereed) PublishedText
Abstract [en]

The PET tracer C-11-deuterium-L-deprenyl (C-11-DED) has been used to visualize activated astrocytes in vivo in patients with Alzheimer disease (AD). In this multitracer PET study, early-phase C-11-DED and C-11-Pittsburgh compound B (C-11-PiB) (eDED and ePiB, respectively) were compared as surrogate markers of brain perfusion, and the extent to which C-11-DED binding is influenced by brain perfusion was investigated. METHODS: C-11-DED, C-11-PiB, and F-18-FDG dynamic PET scans were obtained in age-matched groups comprising AD patients (n = 8), patients with mild cognitive impairment (n = 17), and healthy controls (n = 16). A modified reference Patlak model was used to quantify C-11-DED binding. A simplified reference tissue model was applied to both C-11-DED and C-11-PiB to measure brain perfusion relative to the cerebellar gray matter (R-1) and binding potentials. C-11-PiB retention and F-18-FDG uptake were also quantified as target-to-pons SUV ratios in 12 regions of interest (ROIs). RESULTS: The strongest within-subject correlations with the corresponding R-1 values (R-1,R-DED and R-1,R-PiB, respectively) and with F-18-FDG uptake were obtained when the eDED and ePiB PET data were measured 1-4 min after injection. The optimum eDED/ePiB intervals also showed strong, significant ROI-based intersubject Pearson correlations with R-1,R-DED/R-1,R-PiB and with F-18-FDG uptake, whereas C-11-DED binding was largely independent of brain perfusion, as measured by eDED. Corresponding voxelwise correlations confirmed the ROI-based results. Temporoparietal eDED or ePiB brain perfusion measurements were highly discriminative between patient and control groups, with discriminative ability statistically comparable to that of temporoparietal F-18-FDG glucose metabolism. Hypometabolism extended over wider regions than hypoperfusion in patient groups compared with controls. CONCLUSION: The 1- to 4-min early-frame intervals of C-11-DED or C-11-PiB are suitable surrogate measures for brain perfusion. C-11-DED binding is independent of brain perfusion, and thus C-11-DED PET can provide information on both functional (brain perfusion) and pathologic (astrocytosis) aspects from a single PET scan. In comparison with glucose metabolism, early-phase C-11-DED and C-11-PiB perfusion appear to provide complementary rather than redundant information.

Place, publisher, year, edition, pages
2016. Vol. 57, no 7, 1071-1077 p.
Keyword [en]
amyloid, astrocytosis, brain perfusion, early-phase PET
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:uu:diva-300056DOI: 10.2967/jnumed.115.168732ISI: 000378979200016PubMedID: 26912447OAI: oai:DiVA.org:uu-300056DiVA: diva2:950765
Funder
Swedish Research Council, 05817Swedish Foundation for Strategic Research Knut and Alice Wallenberg FoundationThe Karolinska Institutet's Research FoundationThe Swedish Brain FoundationThe Dementia Association - The National Association for the Rights of the DementedEU, FP7, Seventh Framework ProgrammeStiftelsen Gamla TjänarinnorWenner-Gren Foundations
Available from: 2016-08-02 Created: 2016-08-02 Last updated: 2016-08-02Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Wall, AndersLångström, Bengt
By organisation
RadiologyOrganic Chemistry
In the same journal
Journal of Nuclear Medicine
Radiology, Nuclear Medicine and Medical Imaging

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 39 hits
ReferencesLink to record
Permanent link

Direct link