uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Investigating the association between allergen-specific immunoglobulin E, cancer risk and survival
Kings Coll London, Div Canc Studies, Canc Epidemiol Grp, London, England.;Gadjah Mada Univ, Fac Med, Div Hematol Oncol, Yogyakarta, Indonesia..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Endocrine Surgery. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center. Kings Coll London, Div Canc Studies, Canc Epidemiol Grp, London, England..
Kings Coll London, Div Canc Studies, Canc Epidemiol Grp, London, England.;Reg Canc Ctr, Uppsala, Sweden..
Kings Coll London, Guys & St Thomass Hosp, NIHR Biomed Res Ctr, St Johns Inst Dermatol,Div Genet & Mol Med,Fac Li, London, England.;Kings Coll London, London, England..
Show others and affiliations
2016 (English)In: Oncoimmunology, ISSN 2162-4011, E-ISSN 2162-402X, Vol. 5, no 6, e1154250Article in journal (Refereed) PublishedText
Abstract [en]

Prior findings linking allergy and cancer have been inconsistent, which may be driven by diverse assessment methods. We used serum specific immunoglobulin E (IgE) against common inhalant allergens that was assessed prior to cancer diagnosis in studying this association. We selected 8,727 Swedish men and women who had measurements of serum allergen-specific IgE and total IgE between 1992 and 1996. Multivariable Cox regression using age as a timescale was performed to assess the associations of IgE sensitization, defined by any levels of serum specific IgE >= 35 kU/L, with risk of overall and specific cancers. A test for trend was performed by assigning scores derived from allergen-specific IgE levels at baseline as an ordinal scale. Kaplan-Meier curves and log-rank test were used to assess cancer survival by IgE sensitization status. During a mean follow-up of 16 year, 689 persons were diagnosed with cancer. We found an inverse association between IgE sensitization and cancer risk, with a hazard ratio (HR) of 0.83 and 95% confidence intervals (CI) of 0.70-0.99. A similar trend was seen with specific IgE scores overall (P-trend = 0.007) and in women (P-trend = 0.01). Although IgE sensitization was not associated with risk of common site-specific cancers, serum specific IgE scores were inversely associated with melanoma risk in men and women combined, and with risk of female breast and gynecological cancers combined. No association with survival was observed. The association between circulating IgE levels and incident cancer may point toward a role of T-helper 2 (T(H)2)-biased response in development of some cancers.

Place, publisher, year, edition, pages
2016. Vol. 5, no 6, e1154250
Keyword [en]
Allergy, atopy, cancer, immunoglobulin E, cohort
National Category
Cancer and Oncology
URN: urn:nbn:se:uu:diva-300102DOI: 10.1080/2162402X.2016.1154250ISI: 000379162700021OAI: oai:DiVA.org:uu-300102DiVA: diva2:950819
EU, European Research Council
Available from: 2016-08-02 Created: 2016-08-02 Last updated: 2016-08-02Bibliographically approved

Open Access in DiVA

fulltext(798 kB)12 downloads
File information
File name FULLTEXT01.pdfFile size 798 kBChecksum SHA-512
Type fulltextMimetype application/pdf

Other links

Publisher's full text

Search in DiVA

By author/editor
Holmberg, Lars
By organisation
Endocrine SurgeryUCR-Uppsala Clinical Research Center
In the same journal
Cancer and Oncology

Search outside of DiVA

GoogleGoogle Scholar
Total: 12 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 17 hits
ReferencesLink to record
Permanent link

Direct link