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Determinants of genetic diversity
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Evolutionary Biology.
Univ Montpellier 2, French Natl Ctr Sci Res CNRS, Inst Evolutionary Sci, Pl E Bataillon, F-34095 Montpellier, France..
2016 (English)In: Nature reviews genetics, ISSN 1471-0056, E-ISSN 1471-0064, Vol. 17, no 7, 422-433 p.Article, review/survey (Refereed) PublishedText
Abstract [en]

Genetic polymorphism varies among species and within genomes, and has important implications for the evolution and conservation of species. The determinants of this variation have been poorly understood, but population genomic data from a wide range of organisms now make it possible to delineate the underlying evolutionary processes, notably how variation in the effective population size (Ne) governs genetic diversity. Comparative population genomics is on its way to providing a solution to 'Lewontin's paradox' - the discrepancy between the many orders of magnitude of variation in population size and the much narrower distribution of diversity levels. It seems that linked selection plays an important part both in the overall genetic diversity of a species and in the variation in diversity within the genome. Genetic diversity also seems to be predictable from the life history of a species.

Place, publisher, year, edition, pages
2016. Vol. 17, no 7, 422-433 p.
National Category
Genetics
Identifiers
URN: urn:nbn:se:uu:diva-300131DOI: 10.1038/nrg.2016.58ISI: 000378088700013PubMedID: 27265362OAI: oai:DiVA.org:uu-300131DiVA: diva2:950866
Funder
Swedish Research Council, 2010-5650; 2013-8271EU, European Research Council, AdG 249976; AdG 232971Knut and Alice Wallenberg Foundation
Available from: 2016-08-03 Created: 2016-08-03 Last updated: 2016-08-03Bibliographically approved

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