uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Nanostructure and pore size control of template-free synthesised mesoporous magnesium carbonate
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials. (Nanoteknologi och funktionella material)
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials. (Nanotechnology and Functional Materials)
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials. (Nanotechnology and Functional Materials)
Stockholm Univ, Dept Mat & Environm Chem, SE-10691 Stockholm, Sweden.
Show others and affiliations
2016 (English)In: RSC Advances, Vol. 6, no 78, 74241-74249 p.Article in journal (Refereed) Published
Resource type
Text
Abstract [en]

The structure of mesoporous magnesium carbonate (MMC) first presented in 2013 is investigated using a bottom-up approach. MMC is found to be built from the aggregation of nanoparticles of amorphous MgCO3 and MgO with a coating of amorphous MgCO3. The nanoparticles have dimensions of approximately 2-5 nm as observed using transmission electron microscopy and the aggregation of the particles creates the pore structure of MMC. We further show that the average pore diameter of MMC can be controlled by varying the temperature during the powder formation process and demonstrate that altering the pore size opens the possibility to tune the amorphous phase stabilisation properties that MMC exerts on poorly soluble drug compounds. Specifically, we show the loading and release of the antifungal drug itraconazole using MMC as a drug carrier.

Place, publisher, year, edition, pages
2016. Vol. 6, no 78, 74241-74249 p.
National Category
Nano Technology
Research subject
Engineering Science with specialization in Nanotechnology and Functional Materials
Identifiers
URN: urn:nbn:se:uu:diva-300220DOI: 10.1039/C6RA14171DISI: 000381513600033OAI: oai:DiVA.org:uu-300220DiVA: diva2:951129
Funder
Swedish Research Council, 2014-3929Swedish Energy Agency, P38273-1Knut and Alice Wallenberg Foundation
Available from: 2016-08-05 Created: 2016-08-05 Last updated: 2016-11-30Bibliographically approved
In thesis
1. Mesoporous magnesium carbonate as a drug delivery vehicle for stabilising amorphous drugs and regulating their release rate
Open this publication in new window or tab >>Mesoporous magnesium carbonate as a drug delivery vehicle for stabilising amorphous drugs and regulating their release rate
2016 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

In today’s drug discovery, the number of candidate drugs based on new molecular entities with poor aqueous solubility is increasing. Since poor aqueous solubility of an active pharmaceutical ingredients (APIs) is associated with low bioavailability and thus limite their therapeutic effect, this is often a great challenge in the development of new drugs when oral administration is the preferred route of administration. A number of different strategies have been developed to circumvent this problem where salt formulations of an API is the most widely employed method. However, new strategies are needed since there is no one solution that solves this issue for all substances. In recent time, the concept of stabilizing poorly soluble APIs in their amorphous form has gained a lot of attention since amorphous compounds exhibit a higher apparent solubility compared to their crystalline counterparts. Amorphous substances are prone to crystallize if left in a non-constricted environment and thus need to be stabilized if the amorphous state is to be conserved until administration. Inorganic mesoporous materials have been proposed as an interesting type of excipients that can conserve the amorphous state of APIs.

In this work, the focus was to investigate the possibilities of using a mesoporous type of magnesium carbonate to stabilize the amorphous state of different APIs. Due to the nanometer sized pores in the material, complete conservation of amorphous APIs was obtained. This resulted in both an increase in in vitro release rate and a higher solubility of the substances which may translate to both a faster onset of action and an improved therapeutic effect of the APIs in a clinical situation. The long term stability of formulations was also investigated showing promising results.

The results presented in this work show that mesoporous magnesium carbonate represents an interesting type of excipient for oral formulations of APIs with poor aqueous solubility.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2016. 68 p.
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology, ISSN 1651-6214 ; 1452
Keyword
mesoporous, magnesium carbonate, drug delivery, solubility enhancement, bioavailability, pharmacokinetics, diffusion release, controlled release
National Category
Engineering and Technology
Research subject
Engineering Science with specialization in Nanotechnology and Functional Materials
Identifiers
urn:nbn:se:uu:diva-303832 (URN)978-91-554-9752-1 (ISBN)
Public defence
2016-11-11, Ång/2001, Ångströmlaboratoriet, Lägerhyddsvägen 1, Uppsala, 09:30 (English)
Opponent
Supervisors
Note

Felaktigt ISBN 978-91-554-9702-6 i tryck version.

Available from: 2016-10-20 Created: 2016-09-25 Last updated: 2016-11-18

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Cheung, OceanZhang, PengFrykstrand, SaraStrömme, Maria
By organisation
Nanotechnology and Functional Materials
Nano Technology

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 529 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf