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In vivo imaging of beta cells with radiotracers: state of the art, prospects and recommendations for development and use
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Division of Molecular Imaging. Univ Turku, Turku PET Ctr, Turku, Finland.;Abo Akad Univ, Dept Biosci, Turku, Finland..
NIDDK, NIH, Bethesda, MD 20892 USA..
Radboud Univ Nijmegen, Dept Radiol & Nucl Med, Med Ctr, POB 9101, NL-6500 HB Nijmegen, Netherlands..ORCID iD: 0000-0001-5755-1477
Univ Turku, Turku PET Ctr, Turku, Finland..
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2016 (English)In: Diabetologia, ISSN 0012-186X, E-ISSN 1432-0428, Vol. 59, no 7, 1340-1349 p.Article, review/survey (Refereed) PublishedText
Abstract [en]

Radiotracer imaging is characterised by high in vivo sensitivity, with a detection limit in the lower picomolar range. Therefore, radiotracers represent a valuable tool for imaging pancreatic beta cells. High demands are made of radiotracers for in vivo imaging of beta cells. Beta cells represent only a small fraction of the volume of the pancreas (usually 1-3%) and are scattered in the tiny islets of Langerhans throughout the organ. In order to be able to measure a beta cell-specific signal, one has to rely on highly specific tracer molecules because current in vivo imaging technologies do not allow the resolution of single islets in humans non-invasively. Currently, a considerable amount of preclinical data are available for several radiotracers and three are under clinical evaluation. We summarise the current status of the evaluation of these tracer molecules and put forward recommendations for their further evaluation.

Place, publisher, year, edition, pages
2016. Vol. 59, no 7, 1340-1349 p.
Keyword [en]
Beta cell, Beta cell imaging, Diabetes, Exendin, Islet imaging, Islets of Langerhans, PET, Review, SPECT
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:uu:diva-300377DOI: 10.1007/s00125-016-3959-7ISI: 000378047800002PubMedID: 27094935OAI: oai:DiVA.org:uu-300377DiVA: diva2:951392
Available from: 2016-08-08 Created: 2016-08-08 Last updated: 2016-08-08Bibliographically approved

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Eriksson, OlofBrom, Maarten
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