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Autoantibodies Targeting a Collecting Duct-Specific Water Channel in Tubulointerstitial Nephritis.
Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Autoimmunity. Karolinska Inst, Karolinska Univ Hosp, Dept Med Solna, SE-17176 Stockholm, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
Uppsala University, Science for Life Laboratory, SciLifeLab. Karolinska Inst, Karolinska Univ Hosp, Dept Med Solna, SE-17176 Stockholm, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Autoimmunity. Uppsala University, Science for Life Laboratory, SciLifeLab. Karolinska Inst, Karolinska Univ Hosp, Dept Med Solna, SE-17176 Stockholm, Sweden.
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2016 (English)In: Journal of the American Society of Nephrology, ISSN 1046-6673, E-ISSN 1533-3450, Vol. 27, no 10, 3220-3228 p.Article in journal (Refereed) Published
Abstract [en]

Tubulointerstitial nephritis is a common cause of kidney failure and may have diverse etiologies. This form of nephritis is sometimes associated with autoimmune disease, but the role of autoimmune mechanisms in disease development is not well understood. Here, we present the cases of three patients with autoimmune polyendocrine syndrome type 1 who developed tubulointerstitial nephritis and ESRD in association with autoantibodies against kidney collecting duct cells. One of the patients developed autoantibodies targeting the collecting duct-specific water channel aquaporin 2, whereas autoantibodies of the two other patients reacted against the HOXB7 or NFAT5 transcription factors, which regulate the aquaporin 2 promoter. Our findings suggest that tubulointerstitial nephritis developed in these patients as a result of an autoimmune insult on the kidney collecting duct cells.

Place, publisher, year, edition, pages
2016. Vol. 27, no 10, 3220-3228 p.
National Category
Rheumatology and Autoimmunity
Research subject
Medical Science
Identifiers
URN: urn:nbn:se:uu:diva-300411DOI: 10.1681/ASN.2015101126ISI: 000384628500030PubMedID: 26984885OAI: oai:DiVA.org:uu-300411DiVA: diva2:951403
Funder
Swedish Research CouncilSwedish Research Council FormasSwedish Rheumatism AssociationNovo NordiskTorsten Söderbergs stiftelseRagnar Söderbergs stiftelse
Available from: 2016-08-08 Created: 2016-08-08 Last updated: 2016-11-09Bibliographically approved

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Landegren, NilsHagforsen, EvaNordmark, GunnelGustafsson, JanLarsson, ErikRorsman, FredrikKämpe, Olle
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Science for Life Laboratory, SciLifeLabAutoimmunityDepartment of Medical SciencesDermatology and VenereologyRheumatologyPediatricsDepartment of Immunology, Genetics and PathologyGastroenterology/Hepatology
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Journal of the American Society of Nephrology
Rheumatology and Autoimmunity

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