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Cystatin C vs creatinine as markers of renal function in patients on digoxin treatment
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Osteoporos)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Osteoporos)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
2004 (English)In: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 109, no 3, 247-253 p.Article in journal (Other academic) Published
Abstract [en]

BACKGROUND: The kidney function is a major determinant of the serum concentration of digoxin as this drug is mainly eliminated unchanged through the kidneys. Since digoxin is widely prescribed among the elderly, and the glomerular filtration rate (GFR) declines with age, it is important that the clinician takes the patient's GFR into account when prescribing digoxin. Serum cystatin C has been suggested to be superior to creatinine for estimation of GFR, which may have relevance for the optimization of treatment with digoxin. METHODS: To evaluate which of the two GFR markers serum creatinine and serum cystatin C that best correlates with serum digoxin, we compared the serum levels of digoxin with the serum levels of creatinine and cystatin C in 149 patients on therapeutic drug monitoring of digoxin at our hospital. RESULTS: Overall, there was a stronger correlation between serum digoxin concentrations and cystatin C (p=0.00001) as compared to creatinine (p= 0.00003). Interestingly, of the patients with a serum digoxin concentration > or = 1.5 nmol/L, 29% had a serum creatinine level within normal limits, as compared to 20% with normal cystatin C levels. CONCLUSIONS: In this study, serum cystatin C correlated better to serum digoxin than did serum creatinine. With improved GFR monitoring, digoxin concentrations should be better controlled.

Place, publisher, year, edition, pages
2004. Vol. 109, no 3, 247-253 p.
Keyword [en]
Adult, Angiogenic Proteins/analysis/blood, Antirheumatic Agents/pharmacology, Arthritis/*diagnosis, Arthritis; Rheumatoid/*diagnosis, Biological Markers/analysis, C-Reactive Protein/analysis, Diagnosis; Differential, Female, Fibroblast Growth Factor 2/*analysis/blood, Humans, Male, Middle Aged, Research Support; Non-U.S. Gov't, Steroids/pharmacology, Synovial Fluid/*chemistry/drug effects, Vascular Endothelial Growth Factor A/*analysis/blood
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-67248PubMedID: 15508527OAI: oai:DiVA.org:uu-67248DiVA: diva2:95159
Available from: 2005-05-31 Created: 2005-05-31 Last updated: 2017-11-28Bibliographically approved

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Hallberg, PärMelhus, HåkanLarsson, Anders

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