The Drosophila ortholog of TMEM18 regulates insulin and glucagon-like signaling
2016 (English)In: Journal of Endocrinology, ISSN 0022-0795, E-ISSN 1479-6805, Vol. 229, no 3, 233-243 p.Article in journal (Refereed) PublishedText
Transmembrane protein 18 (TMEM18) is an ill-described, obesity-related gene, but few studies have explored its molecular function. We found single-nucleotide polymorphism data, suggesting that TMEM18 may be involved in the regulation/physiology of metabolic syndrome based on associations with insulin, homeostatic model assessment-beta (HOMA beta), triglycerides, and blood sugar. We then found an ortholog in the Drosophila genome, knocked down Drosophila Tmem18 specifically in insulin-producing cells, and tested for its effects on metabolic function. Our results suggest that TMEM18 affects substrate levels through insulin and glucagon signaling, and its downregulation induces a metabolic state resembling type 2 diabetes. This work is the first to experimentally describe the metabolic consequences of TMEM18 knockdown, and further supports its association with obesity.
Place, publisher, year, edition, pages
2016. Vol. 229, no 3, 233-243 p.
Drosophila, fly, insulin, obesity, SNP, TMEM18, CG30051, glucagon, AKH
Endocrinology and Diabetes
IdentifiersURN: urn:nbn:se:uu:diva-300572DOI: 10.1530/JOE-16-0040ISI: 000379384500007PubMedID: 27029472OAI: oai:DiVA.org:uu-300572DiVA: diva2:951661
FunderSwedish Research Council