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Compression analysis for assessment of pellet plasticity: Identification of reactant pores and comparison between Heckel, Kawakita, and Adams equations
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
2016 (English)In: Chemical engineering research & design, ISSN 0263-8762, E-ISSN 1744-3563, Vol. 110, 183-191 p.Article in journal (Refereed) PublishedText
Abstract [en]

The issue of accurate derivation of a granule yield stress by the traditional procedure using the Heckel equation in addition to the Kawakita and Adams equations has been addressed. The accuracy of the derived parameters was assessed from comparison of single-particle yield pressures from uniaxial compressions. The single-particle yield pressure was nearly four-fold higher for microcrystalline pellets of low (LP) compared to of high (HP) porosity. Heckel profiles were derived using in situ (in-die) and ex situ (out-of-die) global porosities and ex situ voidage porosities derived from mercury porosimetry of pellets and retrieved pellets from tablets. The voidage Heckel profiles enabled a clear distinction between the LP and HP pellets in contrast to the global Heckel profiles. Thus, the voidage was concluded as a better descriptor of the effective porosity of the reactant pore system than the global porosity for calculations of the Heckel numbers. Due to the challenging and tedious work of deriving precise voidage data, derivation of Kawakita b(-1) and Adams parameters remains an interesting approach for assessing granule plasticity. These clearly differentiated between the HP and LP plasticity, thus suggesting that both parameters can be used as a descriptor of pellet plasticity in analytical powder compression analysis.

Place, publisher, year, edition, pages
2016. Vol. 110, 183-191 p.
Keyword [en]
Compression, Heckel equation, Effective porosity, Plasticity, Kawakita equation, Adams equation
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
URN: urn:nbn:se:uu:diva-300565DOI: 10.1016/j.cherd.2016.01.028ISI: 000379106600020OAI: oai:DiVA.org:uu-300565DiVA: diva2:951671
Conference
7th International Granulation Workshop, JUN 29-JUL 03, 2015, Sheffield, ENGLAND
Available from: 2016-08-09 Created: 2016-08-09 Last updated: 2016-08-09Bibliographically approved

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Persson, Ann-SofieNordström, JosefinaFrenning, GöranAlderborn, Göran
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Chemical engineering research & design
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)

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