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Clinical characteristics and late effects in CNS tumours of childhood: Do not forget long term follow-up of the low grade tumours
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Pediatrics.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Pediatrics.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Pediatrics.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology.
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2016 (English)In: European journal of paediatric neurology, ISSN 1090-3798, E-ISSN 1532-2130, Vol. 20, no 4, 580-587 p.Article in journal (Refereed) PublishedText
Abstract [en]

Aim: To investigate clinical characteristics and late effects of CNS tumours in childhood with a special focus on low-grade tumours, especially low-grade astrocytoma and glib neuronal tumours. Methods: A retrospective population based study was performed at Uppsala University Children's Hospital, a tertiary referral centre for children with CNS tumours. Patients were identified from the National Brain Tumour Registry and the National Epilepsy Surgery Registry. Hospital medical records were analysed for patients with a follow up of >= 5 years after diagnosis. A re-evaluation of the neuro-pathological diagnosis was performed. Results: A total of 193 patients (age 0-17.99 years) during a twelve-year period (1995-2006) were included; 149 survived >= 5 years. Three larger subgroups could be identified: astrocytic, embryonal and glioneuronal tumours. A supratentorial location was found in 52%. Medical late effects were mainly neurological and endocrinological, affecting 81% and 26% of surviving patients. Cognitive late effects were a frequent finding in the whole group but also in low-grade astrocytoma and glioneuronal tumours (53% and 67%). Thirty per cent had some kind of pedagogic support in school. Conclusion: Late effects are common in long-term survivors of CNS tumours in childhood. Low-grade astrocytoma and glioneuronal tumours are no exception, and the findings support the need for long-term follow up.

Place, publisher, year, edition, pages
2016. Vol. 20, no 4, 580-587 p.
Keyword [en]
Childhood, CNS-tumour, Cognitive, Late effects, Low grade
National Category
Neurology Pediatrics
Identifiers
URN: urn:nbn:se:uu:diva-300544DOI: 10.1016/j.ejpn.2016.04.009ISI: 000379106700014PubMedID: 27157245OAI: oai:DiVA.org:uu-300544DiVA: diva2:951713
Available from: 2016-08-10 Created: 2016-08-09 Last updated: 2016-08-10Bibliographically approved

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Ehrstedt, ChristofferKristiansen, IngelaAhlsten, GunnarCasar-Borota, OliveraDahl, MargaretaLibard, SylwiaStrömberg, Bo
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PediatricsDepartment of Immunology, Genetics and Pathology
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European journal of paediatric neurology
NeurologyPediatrics

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