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Mechanisms of TGF beta-Induced Epithelial-Mesenchymal Transition
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research.
2016 (English)In: JOURNAL OF CLINICAL MEDICINE, ISSN 2077-0383, Vol. 5, no 7, 63Article, review/survey (Refereed) Published
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Abstract [en]

Transitory phenotypic changes such as the epithelial-mesenchymal transition (EMT) help embryonic cells to generate migratory descendants that populate new sites and establish the distinct tissues in the developing embryo. The mesenchymal descendants of diverse epithelia also participate in the wound healing response of adult tissues, and facilitate the progression of cancer. EMT can be induced by several extracellular cues in the microenvironment of a given epithelial tissue. One such cue, transforming growth factor beta (TGF beta), prominently induces EMT via a group of specific transcription factors. The potency of TGF beta is partly based on its ability to perform two parallel molecular functions, i.e. to induce the expression of growth factors, cytokines and chemokines, which sequentially and in a complementary manner help to establish and maintain the EMT, and to mediate signaling crosstalk with other developmental signaling pathways, thus promoting changes in cell differentiation. The molecules that are activated by TGF beta signaling or act as cooperating partners of this pathway are impossible to exhaust within a single coherent and contemporary report. Here, we present selected examples to illustrate the key principles of the circuits that control EMT under the influence of TGF beta.

Place, publisher, year, edition, pages
2016. Vol. 5, no 7, 63
Keyword [en]
epithelial-mesenchymal transition, signal transduction, transcription factor, transforming growth factor beta, tumor invasiveness
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:uu:diva-300638DOI: 10.3390/jcm5070063ISI: 000379369400004OAI: oai:DiVA.org:uu-300638DiVA: diva2:951770
Available from: 2016-08-10 Created: 2016-08-10 Last updated: 2016-08-10Bibliographically approved

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Moustakas, AristidisHeldin, Carl-Henrik

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