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Recent advances in capillary electrophoretic migration techniques for pharmaceutical analysis (2013-2015)
TU Braunschweig, Inst Med & Pharmaceut Chem, D-38106 Braunschweig, Germany..
TU Braunschweig, Inst Med & Pharmaceut Chem, D-38106 Braunschweig, Germany..
Univ Jeddah, Dept Chem, Fac Sci, Jeddah, Saudi Arabia.;Assiut Univ, Dept Chem, Fac Sci, Assiut, Egypt..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Analytical Pharmaceutical Chemistry. Kantisto BV, Baarn, Netherlands.;Univ Tasmania, Australian Ctr Res Separat Sci ACROSS, Sch Chem, Hobart, Tas, Australia..
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2016 (English)In: Electrophoresis, ISSN 0173-0835, E-ISSN 1522-2683, Vol. 37, no 12, 1591-1608 p.Article, review/survey (Refereed) PublishedText
Abstract [en]

This review updates and follows-up a previous review by highlighting recent advancements regarding capillary electromigration methodologies and applications in pharmaceutical analysis. General approaches such as quality by design as well as sample injection methods and detection sensitivity are discussed. The separation and analysis of drug-related substances, chiral CE, and chiral CE-MS in addition to the determination of physicochemical constants are addressed. The advantages of applying affinity capillary electrophoresis in studying receptor-ligand interactions are highlighted. Finally, current aspects related to the analysis of biopharmaceuticals are reviewed. The present review covers the literature between January 2013 and December 2015.

Place, publisher, year, edition, pages
2016. Vol. 37, no 12, 1591-1608 p.
Keyword [en]
Biopharmaceuticals, Capillary electrophoresis, Pharmaceutical analysis, Quantitation
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
URN: urn:nbn:se:uu:diva-300633DOI: 10.1002/elps.201600058ISI: 000379132300001PubMedID: 26988029OAI: oai:DiVA.org:uu-300633DiVA: diva2:951801
Available from: 2016-08-10 Created: 2016-08-10 Last updated: 2016-08-10Bibliographically approved

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Sänger-van de Griend, Cari
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Analytical Pharmaceutical Chemistry
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Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)

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