Recent advances in capillary electrophoretic migration techniques for pharmaceutical analysis (2013-2015)
2016 (English)In: Electrophoresis, ISSN 0173-0835, E-ISSN 1522-2683, Vol. 37, no 12, 1591-1608 p.Article, review/survey (Refereed) PublishedText
This review updates and follows-up a previous review by highlighting recent advancements regarding capillary electromigration methodologies and applications in pharmaceutical analysis. General approaches such as quality by design as well as sample injection methods and detection sensitivity are discussed. The separation and analysis of drug-related substances, chiral CE, and chiral CE-MS in addition to the determination of physicochemical constants are addressed. The advantages of applying affinity capillary electrophoresis in studying receptor-ligand interactions are highlighted. Finally, current aspects related to the analysis of biopharmaceuticals are reviewed. The present review covers the literature between January 2013 and December 2015.
Place, publisher, year, edition, pages
2016. Vol. 37, no 12, 1591-1608 p.
Biopharmaceuticals, Capillary electrophoresis, Pharmaceutical analysis, Quantitation
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
IdentifiersURN: urn:nbn:se:uu:diva-300633DOI: 10.1002/elps.201600058ISI: 000379132300001PubMedID: 26988029OAI: oai:DiVA.org:uu-300633DiVA: diva2:951801