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Intra-day variability of cystatin C, creatinine and estimated GFR in intensive care patients
Karolinska Inst, Dept Physiol & Pharmacol, Sect Anaesthesia & Intens Care Med, S-17176 Stockholm, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
Karolinska Inst, Dept Physiol & Pharmacol, Sect Anaesthesia & Intens Care Med, S-17176 Stockholm, Sweden; Austin Hosp, Dept Intens Care, Melbourne, Vic 3084, Australia.
Karolinska Inst, Dept Physiol & Pharmacol, Sect Anaesthesia & Intens Care Med, S-17176 Stockholm, Sweden.
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2016 (English)In: Clinica Chimica Acta, ISSN 0009-8981, E-ISSN 1873-3492, Vol. 460, 1-4 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Markers of renal function are widely used in intensive care and sudden changes are important indicators of acute kidney injury. The problem is to distinguish between disease progression/improvement from the natural variation in the patient. The aim of the present study was thus to study the normal intraday variation in ICU patients.

METHODS: We studied the intra-day variation of creatinine, cystatin C and estimated GFR based on these two markers in 28 clinically stable ICU patients.

RESULTS: The median diurnal coefficient of variation sCV) for creatinine was 3.70% (1.92-9.25%) while the median CV for cystatin C was 3.66% (1.36-8.11%). The corresponding CVs for the estimated GFRs were 2.00% (0.89-9.82%) for eGFRcreatinine and 4.60% (1.65-10.24%) for eGFRcystc.

CONCLUSIONS: The eGFRcreatinine values in individual patients were clearly higher than the eGFRcystc values. The median CV for creatinine, cystatin C and the eGFR measurements were below 5% which means that 95% of the test results will vary by <10% between sampling times in stable ICU patients. Differences >10% between sampling times are thus likely to be an indication of changes in biomarker levels due to the disease/treatment.

Place, publisher, year, edition, pages
2016. Vol. 460, 1-4 p.
Keyword [en]
Creatinine; Cystatin C; Critical illness; Renal markers
National Category
Anesthesiology and Intensive Care
Identifiers
URN: urn:nbn:se:uu:diva-300991DOI: 10.1016/j.cca.2016.06.014ISI: 000382352600001PubMedID: 27315745OAI: oai:DiVA.org:uu-300991DiVA: diva2:953152
Available from: 2016-08-16 Created: 2016-08-16 Last updated: 2016-10-05Bibliographically approved

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