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Association between baseline serum glucose, triglycerides and total cholesterol, and prostate cancer risk categories
Kings Coll London, Canc Epidemiol Grp, Div Canc Studies, London, England..
Kings Coll London, Canc Epidemiol Grp, Div Canc Studies, London, England..
Kings Coll London, Canc Epidemiol Grp, Div Canc Studies, London, England.;Reg Canc Ctr, Uppsala, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences. Kings Coll London, Canc Epidemiol Grp, Div Canc Studies, London, England.;Reg Canc Ctr, Uppsala, Sweden..
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2016 (English)In: Cancer Medicine, ISSN 2045-7634, E-ISSN 2045-7634, Vol. 5, no 6, 1307-1318 p.Article in journal (Refereed) PublishedText
Abstract [en]

Lifestyle-related risk factors such as hyperglycemia and dyslipidemia have been associated with several cancers. However, studies exploring their link with prostate cancer (PCa) clinicopathological characteristics are sparse and inconclusive. Here, we investigated the associations between serum metabolic markers and PCa clinicopathological characteristics. The study comprised 14,294 men from the Swedish Apolipoprotein MOrtality RISk (AMORIS) cohort who were diagnosed with PCa between 1996 and 2011. Univariate and multivariable logistic regression were used to investigate the relation between glucose, triglycerides and total cholesterol and PCa risk categories, PSA, Gleason score, and T-stage. Mean age at time of PCa diagnosis was 69 years. Men with glucose levels >6.9 mmol/L tend to have PSA<4 mu g/L, while those with glucose levels of 5.6-6.9 mmol/L had a greater odds of PSA>20 mu g/L compared to PSA 4.0-9.9 mu g/L. Hypertriglyceridemia was also positively associated with PSA>20 mu g/L. Hyperglycemic men had a greater odds of intermediate-and high-grade PCa and advanced stage or metastatic PCa. Similarly, hypertriglyceridemia was positively associated with high-grade PCa. There was also a trend toward an increased odds of intermediate risk localized PCa and advanced stage PCa among men with hypertriglyceridemia. Total cholesterol did not have any statistically significant association with any of the outcomes studied. Our findings suggest that high serum levels of glucose and triglycerides may influence PCa aggressiveness and severity. Further investigation on the role of markers of glucose and lipid metabolism in influencing PCa aggressiveness and severity is needed as this may help define important targets for intervention.

Place, publisher, year, edition, pages
2016. Vol. 5, no 6, 1307-1318 p.
Keyword [en]
Glucose, prostate cancer, total cholesterol, triglycerides
National Category
Cancer and Oncology
URN: urn:nbn:se:uu:diva-301048DOI: 10.1002/cam4.665ISI: 000380048700037PubMedID: 26923095OAI: oai:DiVA.org:uu-301048DiVA: diva2:953661
Swedish Cancer SocietyForte, Swedish Research Council for Health, Working Life and Welfare
Available from: 2016-08-18 Created: 2016-08-17 Last updated: 2016-08-18Bibliographically approved

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