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Convergent in situ assembly of injectable lipogel for enzymatically controlled and targeted delivery of hydrophilic molecules
Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, No. 64 Mianshan Road, Mianyang, 621900, Sichuan Province, China.
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Polymer Chemistry.
Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, No. 64 Mianshan Road, Mianyang, 621900, Sichuan Province, China.
(Institutionen för kemi - Ångström, Department of Chemistry - Ångström)
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2016 (English)In: Carbohydrate Polymers, ISSN 0144-8617, E-ISSN 1879-1344, Vol. 154, 62-69 p.Article in journal (Refereed) Published
Abstract [en]

Applications of liposomes are limited due to their rapid blood clearance and non-specific biodistribution. Surface modification of liposomes could overcome these disadvantages. However, direct coating of liposome surface may cause disruption of liposomes. Herein we present a “top-down” method to coat liposomes in situ with tumor (CD44 receptor) targeting polymer, hyaluronan (HA), by taking advantages of “click” type chemistries and enzymatic degradation. Liposomes entrapped within HA gel were stable without leaking of small cargo molecules from the interior of the liposomes. This injectable liposome-in-hydrogel (lipogel) drug delivery system can achieve sequential two-step release: (1) liposomes release from lipogel after HA degradation; (2) small molecules release from liposomes after the liposomes disruption (either before or after cellular uptake). Similarly to HA coating, this strategy could be used for in situ “top-down” modification of liposomes with other targeting biopolymers. Additionally, it provides the possibility to deliver different types of molecules from two compartments of the lipogel, i.e. large biomacromolecules from the exterior of liposomes and small hydrophilic molecules from the interior of liposomes, locally and systemically.

Place, publisher, year, edition, pages
2016. Vol. 154, 62-69 p.
Keyword [en]
Injectable lipogel; Hyaluronan; In situ coating; Enzymatic degradation; Delivery system
National Category
Biomaterials Science Polymer Chemistry
URN: urn:nbn:se:uu:diva-301127DOI: 10.1016/j.carbpol.2016.08.028OAI: oai:DiVA.org:uu-301127DiVA: diva2:953693
Available from: 2016-08-18 Created: 2016-08-18 Last updated: 2016-08-19

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Publisher's full texthttp://www.sciencedirect.com/science/article/pii/S0144861716309638

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