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Do surface-active lipids in food increase the intestinal permeability to toxic substances and allergenic agents?
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Friman)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
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2004 (English)In: Medical Hypotheses, ISSN 0306-9877, Vol. 63, no 4, 724-30 p.Article in journal (Other academic) Published
Abstract [en]

The incidence of many common diseases has increased during the last decades. High fat intake is a risk factor for many diseases. We propose that some of the negative effects of fat are caused by lipid-induced damage of the gastrointestinal epithelium, thus compromising the epithelial function as a barrier for passage of toxic substances and allergenic agents to the circulatory system. Monoglycerides (MGs), phospholipids and fatty acids (FAs) are surface-active molecules that in pharmaceutical studies act as permeability enhancers for hydrophilic drugs with low absorption. Three possible mechanisms were proposed: (a) lipid-induced alterations in intracellular events may cause destabilization of tight junctions between the GI epithelial cells, (b) lipids may destabilize cell membranes, (c) lipids cause intestinal cell damage, which increase the permeability of the GI epithelium. These "side effects" of lipids may partly explain the association between fat intake and disease observed in epidemiological studies.

Place, publisher, year, edition, pages
2004. Vol. 63, no 4, 724-30 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-67479DOI: 10.1016/j.mehy.2003.10.037PubMedID: 15325024OAI: oai:DiVA.org:uu-67479DiVA: diva2:95390
Available from: 2006-05-19 Created: 2006-05-19 Last updated: 2009-10-27Bibliographically approved

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Publisher's full textPubMedhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=15325024&dopt=Citation

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Carlfors, Johan
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