uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Dyslipidemia and an unfavorable fatty acid profile predict left ventricular hypertrophy 20 years later
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences. (Geriatrics)ORCID iD: 0000-0003-2247-8454
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Akut- och internmedicin)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences. (Clinical Nutrition)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Kardiologi)
Show others and affiliations
2001 (English)In: Circulation, ISSN 0009-7322, E-ISSN 1524-4539, Vol. 103, no 6, 836-841 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND:-Left ventricular hypertrophy (LVH) is a common risk factor for cardiovascular mortality. Causes other than hypertension have not previously been investigated longitudinally. The aim of the present study was to determine hemodynamic, metabolic, and psychosocial predictors at 50 years of age for the prevalence of echocardiographic LVH and geometric subtypes at age 70 by use of a large sample of men from the general population followed up for 20 years. Methods and Results-In 1970 to 1973, all men born from 1920 to 1924 and residing in Uppsala County, Sweden, were invited to participate in a health survey aimed at identifying risk factors for cardiovascular disease. At a reinvestigation 20 years later, echocardiographic left ventricular mass index was determined in 475 subjects. A 1-SD increase in body mass index, systolic or diastolic blood pressure, fasting LDL/HDL cholesterol, serum triglycerides, or the serum cholesterol ester proportion of several saturated fatty acids or oleic acid at age 50 significantly increased the odds of having LVH at age 70 by 27% to 41%, whereas an increase in linoleic acid proportion was protective. Almost all metabolic predictors were independent of ischemic heart disease, valvular disease, and use of antihypertensive medication at age 70. CONCLUSIONS:-Dyslipidemia and indices of a low dietary intake of linoleic acid and high intake of saturated and monounsaturated fats, as well as hypertension and obesity, at age 50 predicted the prevalence of LVH 20 years later in this prospective longitudinal cohort study, thereby suggesting that lipids may be important in the origin of LVH.

Place, publisher, year, edition, pages
2001. Vol. 103, no 6, 836-841 p.
Keyword [en]
Age Factors, Aged, Analysis of Variance, Blood Pressure, Body Mass Index, Cholesterol Esters/*blood, Dietary Fats, Echocardiography; Doppler, Fatty Acids/*blood, Health Surveys, Heart Ventricles/ultrasonography, Hemodynamic Processes, Human, Hyperlipidemia/blood/*complications, Hypertrophy; Left Ventricular/blood/epidemiology/*etiology/ultrasonography, Lipoproteins; HDL Cholesterol/blood, Lipoproteins; LDL Cholesterol/blood, Longitudinal Studies, Male, Middle Aged, Obesity/blood/complications, Odds Ratio, Prospective Studies, Psychology, Risk Factors, Sweden/epidemiology, Time Factors, Triglycerides/blood
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-67494PubMedID: 11171792OAI: oai:DiVA.org:uu-67494DiVA: diva2:95405
Available from: 2008-06-11 Created: 2008-06-11 Last updated: 2017-11-28Bibliographically approved

Open Access in DiVA

No full text

Other links

PubMedhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=11171792&dopt=Citation

Authority records BETA

Sundström, JohanLind, LarsVessby, BengtAndren, BertilLithell, Hans

Search in DiVA

By author/editor
Sundström, JohanLind, LarsVessby, BengtAndren, BertilLithell, Hans
By organisation
Department of Public Health and Caring SciencesDepartment of Medical Sciences
In the same journal
Circulation
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

pubmed
urn-nbn

Altmetric score

pubmed
urn-nbn
Total: 339 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf