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Cardiovascular risk factors and electrographical characteristics and abnormalities in middle-aged males.
Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Medical Sciences.
Department of Public Health and Caring Sciences. Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Medical Sciences.ORCID iD: 0000-0003-2247-8454
Department of Public Health and Caring Sciences.
1997 (English)In: J Intern Med, ISSN 0954-6820, Vol. 241, no 2, 109-13 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES: To evaluate if characteristics and abnormalities found at the electrocardiogram (ECG) are related to common cardiovascular risk factors included in the insulin-resistance metabolic syndrome. DESIGN: Cross-sectional. SETTING: Tertiary university hospital. SUBJECTS: Over 2000 middle-aged males in whom ECG abnormalities were recorded, together with ECG characteristics measured in a random sample of men with no ECG abnormalities (n = 113). INTERVENTIONS: None. RESULTS: All three components of the metabolic syndrome; elevated blood pressure, dyslipidaemia and hyperinsulinaemia were found to be related to the heart rate (P < 0.002) and the QRS-duration (P < 0.01) and inversely to the QoT-interval (P < 0.05), the early diastolic phase (P < 0.05) and the T-wave amplitude (P < 0.02). The components of the metabolic syndrome was furthermore found to be associated with the occurrence of T-wave abnormalities (n = 64, P < 0.01) and to a lesser degree also to the occurrence of Q-waves (n = 21). CONCLUSIONS: The components of the insulin-resistance metabolic syndrome were related both to certain ECG characteristics in subjects with a normal ECG and to some ECG abnormalities. A raised sympathetic activity is likely to be the link between some of the described associations, whilst coronary heart diseases may explain others.

Place, publisher, year, edition, pages
1997. Vol. 241, no 2, 109-13 p.
Keyword [en]
Blood Pressure, Cardiovascular Diseases/blood/*etiology/*physiopathology, Cross-Sectional Studies, Electrocardiography, Human, Insulin/blood, Insulin Resistance, Male, Middle Aged, Risk Factors, Triglycerides/blood
Identifiers
URN: urn:nbn:se:uu:diva-67496PubMedID: 9077366OAI: oai:DiVA.org:uu-67496DiVA: diva2:95407
Available from: 2008-01-30 Created: 2008-01-30 Last updated: 2016-01-18

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Lind, LarsSundström, Johan

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