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Phosphoryl Choline Introduces Dual Activity in Biomimetic Ionomers
Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Materials Chemistry. Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Materials Chemistry, Polymer Chemistry. polymerkemi.
Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Materials Chemistry. Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Materials Chemistry, Polymer Chemistry. polymerkemi.
Medicinska vetenskapsområdet, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology. Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Materials Chemistry, Polymer Chemistry.
Medicinska vetenskapsområdet, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology. Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Materials Chemistry, Polymer Chemistry.
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2004 (English)In: Journal of the American Chemical Society, no 126, 15350-15351 p.Article in journal (Refereed) Published
Abstract [en]

Dual activity of phosphoryl choline (PC) functional poly(trimethylene

carbonate) (PTMC) was found which induces the zwitterionic biomimetic PC group to form physical cross-links with ionomers in the bulk, and at the same time enrich at the surface of cast films. The formation of zwitterionic domains from a bifunctional PC-PTMC-PC (ionomer) provided firm films with a low elastic modulus in contrast to the tacky PTMC starting material (Mn 3900 g/mol) with poor mechanical performance. In addition, the ionomer possessed improved hemocompatible properties that was explained by the enrichment of PC at the surface, suggesting a way to tailor the mechanical performance of biodegradable PTMC-based ionomers while providing its bioactivity. Tailored elasticity while maintaining hemocompatibility of a biodegradable ionomer should be of particular interest for a variety of in vivo applications.

Place, publisher, year, edition, pages
2004. no 126, 15350-15351 p.
Keyword [en]
biodegradable polymer, ionomer, biomimetic, hemocompatble, phosphoryl choline, tailored elasticity
National Category
Inorganic Chemistry
Identifiers
URN: urn:nbn:se:uu:diva-67509OAI: oai:DiVA.org:uu-67509DiVA: diva2:95420
Available from: 2006-03-21 Created: 2006-03-21 Last updated: 2011-01-12

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Bowden, TimNilsson, BoHong, JaanHilborn, Jöns

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