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“Smart” drug loaded nanoparticle delivery from a self-healing hydrogel enabled by dynamic magnesium–biopolymer chemistry
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Polymer Chemistry.
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Polymer Chemistry.
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Polymer Chemistry.
2016 (English)In: Chemical Communications, ISSN 1359-7345, E-ISSN 1364-548X, Vol. 52, no 74, 11151-11154 p.Article in journal (Refereed) Published
Abstract [en]

We report a strategy to generate a self-healing and pH responsive hydrogel network between drug-loaded nanoparticles and natural polysaccharides via magnesium–bisphosphonate ligand interactions. The injectable drug depot disassembles in a tumor-specific environment, providing localized uptake of the nanoparticles, which is highly appreciated in drug delivery applications and manufacturing of drug-loaded biomaterials using a syringe-based deposition technique.

Place, publisher, year, edition, pages
2016. Vol. 52, no 74, 11151-11154 p.
National Category
Biomaterials Science Polymer Chemistry Engineering and Technology
Identifiers
URN: urn:nbn:se:uu:diva-301659DOI: 10.1039/C6CC05565FISI: 000384202000027PubMedID: 27550535OAI: oai:DiVA.org:uu-301659DiVA: diva2:955006
Available from: 2016-08-24 Created: 2016-08-24 Last updated: 2016-11-30Bibliographically approved

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