“Smart” drug loaded nanoparticle delivery from a self-healing hydrogel enabled by dynamic magnesium–biopolymer chemistry
2016 (English)In: Chemical Communications, ISSN 1359-7345, E-ISSN 1364-548X, Vol. 52, 11151-11154 p.Article in journal (Refereed) Published
We report a strategy to generate a self-healing and pH responsive hydrogel network between drug-loaded nanoparticles and natural polysaccharides via magnesium–bisphosphonate ligand interactions. The injectable drug depot disassembles in a tumor-specific environment, providing localized uptake of the nanoparticles, which is highly appreciated in drug delivery applications and manufacturing of drug-loaded biomaterials using a syringe-based deposition technique.
Place, publisher, year, edition, pages
2016. Vol. 52, 11151-11154 p.
Biomaterials Science Polymer Chemistry Engineering and Technology
IdentifiersURN: urn:nbn:se:uu:diva-301659DOI: 10.1039/C6CC05565FOAI: oai:DiVA.org:uu-301659DiVA: diva2:955006