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Human neutrophil lipocalin: normal levels and use as a marker for invasive infection in the newborn
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. (Övrig pediatrisk forskning/Nordvall)
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2004 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 93, no 4, 534-539 p.Article in journal (Refereed) Published
Abstract [en]

AIM: To evaluate human neutrophil lipocalin (HNL) as a marker of neonatal invasive infection and determine the normal serum levels of HNL in newborns.

METHODS: HNL is released from neutrophil granulocytes and is regarded as a specific marker of neutrophil activity. In 81 newborns < or = 28 d of age with signs of infection on a total of 87 occasions, HNL and C-reactive protein (CRP) were measured at inclusion and on the three following days. As controls, term healthy newborns were recruited at birth (cord blood, n = 45) and at ages 3-5 d (n = 46). Serum HNL was measured by a radioimmunoassay.

RESULTS: 25/87 episodes were classified as infection and 62 as non-proven infection. HNLmax was significantly higher in the infected group (mean 587.6 microg/l) than in the non-proven infected group (mean 217.7 microg/, p < 0.001). HNL peaked at inclusion, 1 d earlier than CRP. In the healthy controls. HNL was the same at 3-5 d of age as at birth (mean 82.4-81.7 microg/l) and similar to normal adult levels.

CONCLUSIONS: The release of HNL is not increased in healthy newborns at birth, but neonatal neutrophils rapidly release HNL upon microbial stimulation in vivo. HNL might be useful as an early marker of neonatal infection.

Place, publisher, year, edition, pages
2004. Vol. 93, no 4, 534-539 p.
Keyword [en]
Acute-Phase Proteins, Bacteremia/*diagnosis, Biological Markers/*blood, Birth Weight, C-Reactive Protein/analysis, Carrier Proteins/*diagnostic use, Comparative Study, Female, Gestational Age, Humans, Infant; Newborn, Male, Neutrophils/*metabolism, Oncogene Proteins, Radioimmunoassay/methods, Sensitivity and Specificity
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-67633DOI: 10.1080/08035250410024754PubMedID: 15188983OAI: oai:DiVA.org:uu-67633DiVA: diva2:95544
Available from: 2005-09-14 Created: 2005-09-14 Last updated: 2010-11-29Bibliographically approved

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Fjaertoft, GustavVenge, Per
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Department of Medical SciencesDepartment of Women's and Children's Health
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