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Reproductive Organ Impairments in Xenopus tropicalis Following Developmental Anti-androgenic Exposure
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
2016 (English)Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

Exposure to endocrine disruptive compounds during critical developmental periods can cause various reproductive impairments in vertebrates. This project aims to investigate physiological reproductive effects in anti-androgen exposed Xenopus tropicalis. Metamorphosing male X. tropicalis were exposed to linuron or flutamide. Testicular histology and biometrical measurements were determined. Both linuron and flutamide caused reproductive organ impairments and decreased body weight. The outcome underscores the amphibian vulnerability to endocrine disruption during critical developmental periods. 

Place, publisher, year, edition, pages
2016. , 24 p.
National Category
Pharmacology and Toxicology
Identifiers
URN: urn:nbn:se:uu:diva-301993OAI: oai:DiVA.org:uu-301993DiVA: diva2:955918
Subject / course
Toxicology
Educational program
Master of Science Programme in Pharmacy
Supervisors
Examiners
Available from: 2016-09-15 Created: 2016-08-26 Last updated: 2016-09-16Bibliographically approved

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ReferencesLink to record
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