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High interstitial fluid pressure - an obstacle in cancer therapy.
Ludwiginstitutet för Cancerforskning.
Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
Ludwiginstitutet för Cancerforskning.
Ludwiginstitutet för Cancerforskning.
2004 (English)In: Nat Rev Cancer, ISSN 1474-175X, Vol. 4, no 10, 806-13 p.Article in journal (Refereed) Published
Abstract [en]

Many solid tumours show an increased interstitial fluid pressure (IFP), which forms a barrier to transcapillary transport. This barrier is an obstacle in tumour treatment, as it results in inefficient uptake of therapeutic agents. There are a number of factors that contribute to increased IFP in the tumour, such as vessel abnormalities, fibrosis and contraction of the interstitial matrix. Lowering the tumour IFP with specific signal-transduction antagonists might be a useful approach to improving anticancer drug efficacy.

Place, publisher, year, edition, pages
2004. Vol. 4, no 10, 806-13 p.
Keyword [en]
Alprostadil/pharmacology, Animals, Antineoplastic Agents/*pharmacokinetics, Biological Transport, Bradykinin/antagonists & inhibitors, Extracellular Fluid/*physiology, Humans, Hyaluronoglucosaminidase/pharmacology, Hydrostatic Pressure, Mice, Neoplasms/blood supply/drug therapy/*physiopathology, Niacinamide/pharmacology, Platelet-Derived Growth Factor/antagonists & inhibitors, Research Support; Non-U.S. Gov't, Signal Transduction/drug effects, Transforming Growth Factor beta/antagonists & inhibitors, Tumor Necrosis Factor-alpha/antagonists & inhibitors, Vascular Endothelial Growth Factor A/antagonists & inhibitors
URN: urn:nbn:se:uu:diva-67997PubMedID: 15510161OAI: oai:DiVA.org:uu-67997DiVA: diva2:95908
Available from: 2005-05-30 Created: 2005-05-30 Last updated: 2011-01-12

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Heldin, Carl-HenrikRubin, Kristofer
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Department of Medical Biochemistry and Microbiology

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