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Polymorphic mutation frequencies in Escherichia coli: emergence of weak mutators in clinical isolates
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2004 (English)In: Journal of Bacteriology, ISSN 0021-9193, E-ISSN 1098-5530, Vol. 186, no 16, 5538-5542 p.Article in journal (Refereed) Published
Abstract [en]

Polymorphisms in the rifampin resistance mutation frequency (f) were studied in 696 Escherichia coli strains from Spain, Sweden, and Denmark. Of the 696 strains, 23% were weakly hypermutable (4 x 10(-8) < or = f < 4 x 10(-7)), and 0.7% were strongly hypermutable (f > or = 4 x 10(-7)). Weak mutators were apparently more frequent in southern Europe and in blood isolates (38%) than in urinary tract isolates (25%) and feces of healthy volunteers (11%).

Place, publisher, year, edition, pages
2004. Vol. 186, no 16, 5538-5542 p.
Keyword [en]
Anti-Bacterial Agents/pharmacology, Blood/microbiology, Denmark, Drug Resistance; Bacterial/*genetics, Escherichia coli/drug effects/*genetics/isolation & purification, Escherichia coli Infections/microbiology, Feces/microbiology, Genes; Bacterial, Humans, Mutation, Polymorphism; Genetic, Research Support; Non-U.S. Gov't, Rifampin/*pharmacology, Spain, Sweden, Urinary Tract Infections/microbiology
Identifiers
URN: urn:nbn:se:uu:diva-68004DOI: 10.1128/JB.186.16.5538-5542.2004PubMedID: 15292159OAI: oai:DiVA.org:uu-68004DiVA: diva2:95915
Available from: 2005-02-09 Created: 2005-02-09 Last updated: 2017-11-21Bibliographically approved

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Andersson, Dan I

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