Polymorphic mutation frequencies in Escherichia coli: emergence of weak mutators in clinical isolates
2004 (English)In: Journal of Bacteriology, ISSN 0021-9193, E-ISSN 1098-5530, Vol. 186, no 16, 5538-5542 p.Article in journal (Refereed) Published
Polymorphisms in the rifampin resistance mutation frequency (f) were studied in 696 Escherichia coli strains from Spain, Sweden, and Denmark. Of the 696 strains, 23% were weakly hypermutable (4 x 10(-8) < or = f < 4 x 10(-7)), and 0.7% were strongly hypermutable (f > or = 4 x 10(-7)). Weak mutators were apparently more frequent in southern Europe and in blood isolates (38%) than in urinary tract isolates (25%) and feces of healthy volunteers (11%).
Place, publisher, year, edition, pages
2004. Vol. 186, no 16, 5538-5542 p.
Anti-Bacterial Agents/pharmacology, Blood/microbiology, Denmark, Drug Resistance; Bacterial/*genetics, Escherichia coli/drug effects/*genetics/isolation & purification, Escherichia coli Infections/microbiology, Feces/microbiology, Genes; Bacterial, Humans, Mutation, Polymorphism; Genetic, Research Support; Non-U.S. Gov't, Rifampin/*pharmacology, Spain, Sweden, Urinary Tract Infections/microbiology
IdentifiersURN: urn:nbn:se:uu:diva-68004DOI: 10.1128/JB.186.16.5538-5542.2004PubMedID: 15292159OAI: oai:DiVA.org:uu-68004DiVA: diva2:95915