uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Amplification-mutagenesis: how growth under selection contributes to the origin of genetic diversity and explains the phenomenon of adaptive mutation
Karolinska Institute, Microbiology and Tumour Biology Center, 171 77, Solna, Sweden.
2004 (English)In: Research in Microbiology, ISSN 0923-2508, Vol. 155, no 5, 342-351 p.Article in journal (Refereed) Published
Abstract [en]

The behavior of a particular bacterial genetic system has been interpreted as evidence that selective stress induces general mutagenesis or even preferentially directs mutations to sites that improve growth (adaptive mutation). It has been proposed that changes in mutability are a programmed response to stress in non-growing cells. In contrast, the amplification-mutagenesis model suggests that stress has no direct effect on the mutation rate and that mutations arise in cells growing under strong selection. In this model, stress serves only as a selective pressure that favors cells with multiple copies of a growth-limiting gene. Mutations are made more probable because more target copies are added to the selection plate-more cells with more mutational targets per cell. The amplification-mutagenesis process involves standard genetic events and therefore should apply to all biological systems. Idiosyncrasies of the particular system described here accelerate this process, allowing an evolutionary series of events to be completed in only a few days.

Place, publisher, year, edition, pages
2004. Vol. 155, no 5, 342-351 p.
Keyword [en]
Amplification–mutagenesis, Adaptive mutation, Stress, Selection
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-68006DOI: 10.1016/j.resmic.2004.01.016PubMedID: 15207866OAI: oai:DiVA.org:uu-68006DiVA: diva2:95917
Available from: 2005-02-09 Created: 2005-02-09 Last updated: 2015-06-25Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMedhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=15207866&dopt=Citation

Search in DiVA

By author/editor
Andersson, Dan I
In the same journal
Research in Microbiology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 279 hits
ReferencesLink to record
Permanent link

Direct link