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Adaptation to the deleterious effects of antimicrobial drug resistance mutations by compensatory evolution
Karolinska Institute, Microbiology and Tumour Biology Center, Stockholm.
2004 (English)In: Research in Microbiology, ISSN 0923-2508, Vol. 155, no 5, 360-369 p.Article in journal (Refereed) Published
Abstract [en]

Compensatory mutations, due to their ability to mask the deleterious effects of another mutation, are important for the adaptation and evolution of most organisms. Resistance to antibiotics, antivirals, antifungals, herbicides and insecticides is usually associated with a fitness cost. As a result of compensatory evolution, the initial fitness costs conferred by resistance mutations (or other deleterious mutations) can often be rapidly and efficiently reduced. Such compensatory evolution is potentially of importance for (i) the long-term persistence of drug resistance, (ii) reducing the rate of fitness loss associated with the accumulation of deleterious mutations in small asexual populations, and (iii) the evolution of complexity of cellular processes.

Place, publisher, year, edition, pages
2004. Vol. 155, no 5, 360-369 p.
Keyword [en]
Antibiotic resistance, Deleterious mutation, Fitness cost, Compensatory mutation, Adaptation
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-68007DOI: 10.1016/j.resmic.2004.01.019PubMedID: 15207868OAI: oai:DiVA.org:uu-68007DiVA: diva2:95918
Available from: 2005-02-09 Created: 2005-02-09 Last updated: 2015-06-25Bibliographically approved

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Andersson, Dan I
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