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Oral imatinib mesylate (STI571/gleevec) improves the efficacy of local intravascular vascular endothelial growth factor-C gene transfer in reducing neointimal growth in hypercholesterolemic rabbits.
Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences. (Vascular Surgery)
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2004 (English)In: Circulation, ISSN 1524-4539, Vol. 109, no 9, 1140-6 p.Article in journal (Refereed) Published
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2004. Vol. 109, no 9, 1140-6 p.
Keyword [en]
Adenoviridae/genetics, Administration; Oral, Animals, Arteries, Cell Division/drug effects, Cell Movement, Combined Modality Therapy, Endothelium; Vascular/pathology, Enzyme Inhibitors/administration & dosage/*therapeutic use, Gene Transfer Techniques, Genetic Vectors/administration & dosage, Hypercholesterolemia/drug therapy/pathology/*therapy, Macrophages/immunology, Muscle; Smooth; Vascular/pathology, Piperazines/administration & dosage/*therapeutic use, Pyrimidines/administration & dosage/*therapeutic use, Rabbits, Receptors; Platelet-Derived Growth Factor/*antagonists & inhibitors, Research Support; Non-U.S. Gov't, Tunica Intima/cytology/drug effects/*pathology, Tunica Media/pathology, Vascular Endothelial Growth Factor C/*genetics
URN: urn:nbn:se:uu:diva-68133PubMedID: 14769706OAI: oai:DiVA.org:uu-68133DiVA: diva2:96044
Available from: 2005-02-15 Created: 2005-02-15 Last updated: 2011-01-12

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Bäckström, GudrunCarlsson, MarianneBergqvist, DavidHeldin, Carl-Henrik
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