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Blood-Spinal Cord and Brain Barriers in Health and Disease: Blood-spinal cord and brain barriers
Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Medical Cell Biology. Department of Surgical Sciences. Anatomy. (Anaesthesiology and Intensive Care)
2004 (English)Book (Other scientific)
Abstract [en]

While the skull protects the human brain from outside trauma, there is an equally effective internal security system made up of tightly attached endothelial cells of the cerebral capillaries, called the blood-brain barrier (BBB). The BBB allows only required elements, such as nutrients and other molecules required by the brain for normal function, to enter the brain's while proteins, toxic substances and other harmful elements are deliberately kept away. Recent research into the anatomy and pathophysiology of these barrier systems suggests that a breakdown of the blood-brain and blood-spinal cord barriers can result in several diseases affecting the central nervous system (CNS). This book presents new findings in the area of blood-brain barrier research that suggest that the blood-brain and blood-spinal cord barriers play important roles in health and disease conditions. The book also discusses the development of new drugs that can modulate the barrier function in the CNS. New knowledge presented in the book may provide new approaches to treat neurological and neurodegenerative diseases such as Alzheimer's disease and other motor neuron diseases, as well as brain and spinal cord trauma. Thus, the time is just ripe for this new volume "Blood-Spinal Cord and Brain Barriers in Health and Disease". With contributions from world leaders in the field, the book presents cutting edge of research. This volume highlights the vital point of this rich field and indicates new avenues for more discoveries to come. This comprehensive volume provides state of the art of basic, clinical and translational research and is an example of a unique treatise in neuroscience.

Place, publisher, year, edition, pages
Elsevier, San Diego , 2004. , 604 p.
National Category
URN: urn:nbn:se:uu:diva-68584ISBN: 0-12-639011-8OAI: oai:DiVA.org:uu-68584DiVA: diva2:96495
This book presentsAvailable from: 2006-05-16 Created: 2006-05-16

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Sharma, Hari Shanker
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Department of Medical Cell BiologyDepartment of Surgical Sciences

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