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Specific patterns of whole-brain structural covariance of the anterior and posterior hippocampus in young APOE ε4 carriers
Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
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(English)Manuscript (preprint) (Other academic)
Keyword [en]
APOE ε4, hippocampus, structural covariance, young adults, partial least squares, memory
National Category
Psychology (excluding Applied Psychology)
Research subject
Psychology
Identifiers
URN: urn:nbn:se:uu:diva-302851OAI: oai:DiVA.org:uu-302851DiVA: diva2:968039
Available from: 2016-09-11 Created: 2016-09-11 Last updated: 2016-09-11
In thesis
1. The Influence of APOE ε4 on the Hippocampus and Hippocampus-Dependent Memory
Open this publication in new window or tab >>The Influence of APOE ε4 on the Hippocampus and Hippocampus-Dependent Memory
2016 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

APOE ε4 is the major genetic risk factor for Alzheimer’s disease, a dementia characterized by memory impairment and hippocampal atrophy. While associated with episodic impairment and reduced hippocampal volume in healthy aging, APOE ε4 has been related to increased episodic memory performance in young adults. The effect of APOE ε4 on hippocampal volume in young age is uncertain, with studies showing comparable or smaller volumes in ε4 carriers. This thesis aims to further explore the effects of APOE ε4 on episodic memory and hippocampal volume in young adults. In addition to episodic memory, spatial memory will also be assessed, as both these memory types are hippocampus-dependent. Furthermore, potential modulating effects of sex are assessed, as sex differences has been found in relation to APOE-related pathology, episodic and spatial memory and hippocampal volume. Study I examined the effects of APOE ε4 on episodic and spatial memory and hippocampal volume in young adults. Hippocampal volume was assessed by manual tracing of the hippocampal head, body and tail. Study II considered whole-brain structural covariance patterns of the anterior and posterior hippocampus. Furthermore, the association between these patterns and episodic and spatial memory performance was assessed. Study III investigated the effects of APOE ε4 on episodic and spatial memory and hippocampal volume in three different age groups. This was done in order to further explore the different effects of APOE ε4 on cognition and hippocampal volume seen in young and older age. In summary, APOE ε4 was positively associated with spatial function and episodic memory in young adults. Although there were no effects of APOE ε4 on hippocampal volume, structural covariance patterns of the anterior and posterior hippocampus differed as a function of APOE ε4 and sex. Thus, structural covariance may provide an early measure of APOE ε4-related effects on brain structure. Moreover, sex was found to modulate the effects of APOE ε4 to the disadvantage of women. This was seen in both age-related hippocampal volume effects and in structural covariance patterns in young adults, as well as in spatial memory performance across age groups.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2016. 85 p.
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Social Sciences, ISSN 1652-9030 ; 130
Keyword
APOE ε4, episodic memory, spatial memory, hippocampus
National Category
Psychology
Identifiers
urn:nbn:se:uu:diva-302855 (URN)978-91-554-9685-2 (ISBN)
Public defence
2016-10-28, Auditorium Minus, Gustavianum, Akademigatan 3, Uppsala, 10:15 (English)
Opponent
Supervisors
Available from: 2016-10-06 Created: 2016-09-11 Last updated: 2016-10-11

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