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THE DESIGN AND PHARMACOLOGY OF NOVEL SELECTIVE MUSCARINIC AGONISTS AND ANTAGONISTS
Uppsala University.
Uppsala University.
Uppsala University.
Uppsala University.
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1995 (English)In: LIFE SCIENCES, Vol. 56, no 11-12, 815-822 p.Other (Other scientific)
Abstract [en]

The muscarinic pharmacology of Cl-methyl-substituted chiral compounds related to McN-A-343 and of(R)- and (S)-dimethindene has been studied. Among the McN-A-343 analogues, the (S)-enantiomers were more potent and had higher affinity than the (R)-isomers.

Place, publisher, year, pages
PERGAMON-ELSEVIER SCIENCE LTD , 1995. Vol. 56, no 11-12, 815-822 p.
Keyword [en]
MCN-A-343 ANALOGS; (S)-DIMETHINDENE; TRIPITRAMINE; ANOCOCCYGEUS MUSCLE; RECEPTOR SUBTYPES; AFFINITY PROFILES; M1; ANTIMUSCARINICS; METHOCTRAMINE; DIMETHINDENE; ENANTIOMERS; BINDING; BRAIN
Identifiers
URN: urn:nbn:se:uu:diva-69188OAI: oai:DiVA.org:uu-69188DiVA: diva2:97099
Note
Addresses: LAMBRECHT G, UNIV FRANKFURT, DEPT PHARMACOL, D-60439 FRANKFURT, GERMANY. UNIV UPPSALA, DEPT ORGAN PHARMACEUT CHEM, S-75123 UPPSALA, SWEDEN. FREE UNIV BRUSSELS, DEPT BIOCHEM & NUTR, B-1070 BRUSSELS, BELGIUM.Available from: 2008-10-17 Created: 2008-10-17

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