uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Corticotropin-releasing hormone family evolution: five ancestral genes remain in some lineages
Univ Algarve, Ctr Marine Sci, Comparat Endocrinol & Integrat Biol, Campus Gambelas, Faro, Portugal..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Pharmacology. Uppsala University, Science for Life Laboratory, SciLifeLab.
Univ Algarve, Ctr Marine Sci, Comparat Endocrinol & Integrat Biol, Campus Gambelas, Faro, Portugal..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Pharmacology. Uppsala University, Science for Life Laboratory, SciLifeLab.
2016 (English)In: Journal of Molecular Endocrinology, ISSN 0952-5041, E-ISSN 1479-6813, Vol. 57, no 1, 73-86 p.Article in journal (Refereed) Published
Abstract [en]

The evolution of the peptide family consisting of corticotropin-releasing hormone ( CRH) and the three urocortins ( UCN1-3) has been puzzling due to uneven evolutionary rates. Distinct gene duplication scenarios have been proposed in relation to the two basal rounds of vertebrate genome doubling ( 2R) and the teleost fish-specific genome doubling ( 3R). By analyses of sequences and chromosomal regions, including many neighboring gene families, we show here that the vertebrate progenitor had two peptide genes that served as the founders of separate subfamilies. Then, 2R resulted in a total of five members: one subfamily consists of CRH1, CRH2, and UCN1. The other subfamily contains UCN2 and UCN3. All five peptide genes are present in the slowly evolving genomes of the coelacanth Latimeria chalumnae ( a lobe-finned fish), the spotted gar Lepisosteus oculatus ( a basal ray-finned fish), and the elephant shark Callorhinchus milii ( a cartilaginous fish). The CRH2 gene has been lost independently in placental mammals and in teleost fish, but is present in birds ( except chicken), anole lizard, and the nonplacental mammals platypus and opossum. Teleost 3R resulted in an additional surviving duplicate only for crh1 in some teleosts including zebrafish ( crh1a and crh1b). We have previously reported that the two vertebrate CRH/UCN receptors arose in 2R and that CRHR1 was duplicated in 3R. Thus, we can now conclude that this peptide-receptor system was quite complex in the ancestor of the jawed vertebrates with five CRH/UCN peptides and two receptors, and that crh and crhr1 were duplicated in the teleost fish tetraploidization.

Place, publisher, year, edition, pages
2016. Vol. 57, no 1, 73-86 p.
Keyword [en]
CRH/UCN, phylogeny, gene duplication, synteny, chromosome duplication
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-303131DOI: 10.1530/JME-16-0051ISI: 000380717500014PubMedID: 27220618OAI: oai:DiVA.org:uu-303131DiVA: diva2:971152
Funder
Swedish Research Council
Available from: 2016-09-15 Created: 2016-09-15 Last updated: 2016-09-15Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Bergqvist, Christina A.Larhammar, Dan
By organisation
PharmacologyScience for Life Laboratory, SciLifeLab
In the same journal
Journal of Molecular Endocrinology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 25 hits
ReferencesLink to record
Permanent link

Direct link