Molecular Features of Subtype-Specific Progression from Ductal Carcinoma In Situ to Invasive Breast Cancer
2016 (English)In: Cell reports, ISSN 2211-1247, E-ISSN 2211-1247, Vol. 16, no 4, 1166-1179 p.Article in journal (Refereed) Published
McGill Univ, Dept Biochem, Montreal, PQ H3G 1Y6, Canada.;McGill Univ, McGill Ctr Bioinformat, Montreal, PQ H3G 1Y6, Canada.;McGill Univ, Rosalind & Morris Goodman Canc Res Ctr, Montreal, PQ H3A 1A3, Canada..
Aure, Miriam Ragle
Norwegian Radium Hosp, Oslo Univ Hosp, Inst Canc Res, N-0424 Oslo, Norway.;Norwegian Radium Hosp, Oslo Univ Hosp, Dept Canc Genet, N-0424 Oslo, Norway.;Univ Oslo, Inst Clin Med, KG Jebsen Ctr Breast Canc Res, N-0318 Oslo, Norway..
Mörk, Hanne Haberg
Norwegian Radium Hosp, Oslo Univ Hosp, Inst Canc Res, N-0424 Oslo, Norway.;Norwegian Radium Hosp, Oslo Univ Hosp, Dept Canc Genet, N-0424 Oslo, Norway..
Univ Oslo, Oslo Ctr Biostat & Epidemiol, N-0317 Oslo, Norway.;Univ Oslo, Dept Biostat, N-0317 Oslo, Norway. St Olavs Univ Hosp, Dept Oncol, N-7006 Trondheim, Norway..
Breast cancer consists of at least five main molecular "intrinsic'' subtypes that are reflected in both pre-invasive and invasive disease. Although previous studies have suggested that many of the molecular features of invasive breast cancer are established early, it is unclear what mechanisms drive progression and whether the mechanisms of progression are dependent or independent of subtype. We have generated mRNA, miRNA, and DNA copy-number profiles from a total of 59 in situ lesions and 85 invasive tumors in order to comprehensively identify those genes, signaling pathways, processes, and cell types that are involved in breast cancer progression. Our work provides evidence that there are molecular features associated with disease progression that are unique to the intrinsic subtypes. We additionally establish subtype-specific signatures that are able to identify a small proportion of pre-invasive tumors with expression profiles that resemble invasive carcinoma, indicating a higher likelihood of future disease progression.
Place, publisher, year, edition, pages
2016. Vol. 16, no 4, 1166-1179 p.
Cell and Molecular Biology
IdentifiersURN: urn:nbn:se:uu:diva-303121DOI: 10.1016/j.celrep.2016.06.051ISI: 000380265500023PubMedID: 27396337OAI: oai:DiVA.org:uu-303121DiVA: diva2:971239