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Radiation dose distribution in coronary arteries in breast cancer radiotherapy
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Experimental and Clinical Oncology. Gavle Cent Hosp, Dept Oncol, Gavle, Sweden.;Visby Hosp, Sect Oncol, Visby, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Experimental and Clinical Oncology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medical Radiation Science.
Kings Coll London, Fac Life Sci & Med, Div Canc Studies, Guys Campus, London, England.;Uppsala Univ, Univ Hosp, Reg Canc Ctr, Uppsala, Sweden..
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2016 (English)In: Acta Oncologica, ISSN 0284-186X, E-ISSN 1651-226X, Vol. 55, no 8, 959-963 p.Article in journal (Refereed) Published
Abstract [en]

Background: Women irradiated for left-sided breast cancer (BC) have an increased risk of coronary artery disease compared to women with right-sided BC. We describe the distribution of radiation dose in segments of coronary arteries in women receiving adjuvant radiotherapy (RT) for left- or right-sided BC.Material and methods: Fifteen women with BC, seven left-sided and eight right-sided, who had received three-dimensional conformal radiotherapy (3DCRT), constituted the study base. The heart and the segments of the coronary arteries were defined as separate organs at risk (OAR), and the mean and maximum radiation doses were calculated for each OAR.Results: In women with left-sided BC, irrespective of if regional lymph node RT was given or not, maximum dose in mid and distal left anterior descending artery (mdLAD) was approximately 50Gy in 6/7 patients, whereas women with right-sided BC mainly received low doses of radiation. In women with left-sided BC, 6/7 patients had substantially higher mean dose to the distal LAD than to the heart, ranging from 30 to 55Gy and 3 to13Gy, respectively.Conclusion: We found a pronounced difference of radiation dose distribution in the coronary arteries between women with left- and right-sided BC. Women with left-sided BC had almost full treatment dose in parts of mdLAD, regardless of if regional lymph node irradiation was given or not, while women with right-sided BC mainly received low doses to the coronary arteries.

Place, publisher, year, edition, pages
2016. Vol. 55, no 8, 959-963 p.
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:uu:diva-303404DOI: 10.1080/0284186X.2016.1182209ISI: 000381102800003PubMedID: 27230730OAI: oai:DiVA.org:uu-303404DiVA: diva2:971748
Funder
Swedish Cancer Society
Available from: 2016-09-19 Created: 2016-09-19 Last updated: 2016-09-19Bibliographically approved

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Nilsson, GregerNyström, Petra WittIsacsson, UlfDuvernoy, OlovLagerqvist, BoHolmberg, Lars
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Experimental and Clinical OncologyMedical Radiation ScienceRadiologyCardiologyUCR-Uppsala Clinical Research CenterEndocrine Surgery
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